Development of Novel Indolyl-derived Biologically Active Compounds - El Sayed, Mardia
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MRSA is a methicillin-resistance Staphylococcus aureus and a strain of Staphylococcus aureus that developed resistance to the killing effect of the beta-lactam antibiotics, which include the penicillins (methicillin, dicloxacillin, oxacillin, etc.), MRSA is sometimes called a "superbug" because it is very difficult to treat and it causes a huge number of infections every year in hospitals all over the world. The novel synthesized indoles will add a valuable new addition to the antibacterial arsenal for MRSA infections, it would be new bactericidal agents effective against resistant isolates or…mehr

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Produktbeschreibung
MRSA is a methicillin-resistance Staphylococcus aureus and a strain of Staphylococcus aureus that developed resistance to the killing effect of the beta-lactam antibiotics, which include the penicillins (methicillin, dicloxacillin, oxacillin, etc.), MRSA is sometimes called a "superbug" because it is very difficult to treat and it causes a huge number of infections every year in hospitals all over the world. The novel synthesized indoles will add a valuable new addition to the antibacterial arsenal for MRSA infections, it would be new bactericidal agents effective against resistant isolates or standard. We have shown for the first time that the cycloalkanoindoles,bis-indolobenzocarbazoles and the oxidized bis-indolylmethenes inhibited growth of drug resistant MRSA either standard or isolate and other Gram-positive bacteria at low concentrations. Some of these novel bis- and tris-indolyl compounds described in this work have been screened in the national cancer institute (NCI) in USA for one and five dose that showed the highest antipoliferative activity in a nanomolar scale towards the selected cancers cell lines (Non small lung: NCIeH460, Ovarian: OVCAR-4 and Breast: MCF).
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Autorenporträt
Dr. Mardia Telep El Sayed is an Egyptian Assistantprofessor at National Research Center, AppliedOrganic Chemistry Department. In 2013 she receivedher PhD started in Institute of pharmacy, MartinLuther University Halle, Germany. She has BSc andMSc in Organic Chemistry from Egyptian Universities.