Diabetes & C-Peptide

Scientific and Clinical Aspects
Herausgegeben:Sima, Anders A.F.

• Gebundenes Buch

Produktbeschreibung

In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.

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Produktdetails

• Contemporary Diabetes
• Verlag: Humana / Humana Press / Springer, Berlin
• Artikelnr. des Verlages: 80021176, 978-1-61779-390-5
• 2012
• Seitenzahl: 184
• Erscheinungstermin: 3. November 2011
• Englisch
• Abmessung: 260mm x 183mm x 15mm
• Gewicht: 555g
• ISBN-13: 9781617793905
• ISBN-10: 1617793906
• Artikelnr.: 33682910

Inhaltsangabe

Preface.- Foreword.- C-peptide and Insulin - A Happy Marriage.- Peptide Interactions of Proinsulin C-peptide.- he Effect of Combined C-peptide and Zinc on Cellular Function.- C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy.- Role of C-Peptide in the Regulation of Microvascular Blood Flow.- Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy?.- Renoprotective Effects of C-Peptide in Type I Diabetes.- The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy.- C-peptide and Type 1 Diabetic Encephalopathy.- C-peptide: a New Molecule with Anti-Inflammatory Properties.- C-peptide: Connecting Diabetes with Macrovascular Complications.- C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes.- Proatherogenic Effects of C-Peptide.- Conclusions and Future Outlook.

Rezensionen

From the reviews:
"The authors of this volume show in 14 chapters that C-peptide considered and inactive part of proinsulin has a series of metabolic roles. An interesting text. For diabetologists." (Pediatric Endocrinology Reviews (PER), Vol. 9 (3), March, 2012)