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Diabetes is a disease that is rife throughout the world, particularly in developing countries such as Benin. Diabetic nephropathy is a complication of diabetes that leads to extra-renal purification. It is initially asymptomatic, which necessitates early detection. The aim of this study was to determine the level of knowledge and communication with a view to early detection of diabetic nephropathy. It was carried out in the university clinics of Nephrology-Haemodialysis and Endocrinology and Metabolic Diseases at the National Hospital and University Centre in Cotonou. Of the 160 patients included, 4 out of 5 said they knew about diabetes. More than half said that diabetes can be complicated by kidney damage. Three out of four were unaware of the possibility of early detection of diabetic nephropathy. According to these patients, media broadcasts and awareness-raising during medical consultations were the best means of communication. This study highlighted the need to introduce therapeutic education for early detection of diabetic nephropathy.