Mohammad A. Vasef (Professor, Department of Pathology, Director of, Aaron Auerbach (Senior Hematopathologist, Joint Pathology Center, S
Diagnostic Pathology: Molecular Oncology
Mohammad A. Vasef (Professor, Department of Pathology, Director of, Aaron Auerbach (Senior Hematopathologist, Joint Pathology Center, S
Diagnostic Pathology: Molecular Oncology
- Gebundenes Buch
- Merkliste
- Auf die Merkliste
- Bewerten Bewerten
- Teilen
- Produkt teilen
- Produkterinnerung
- Produkterinnerung
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Providing a clear understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer in an era of personalized medicine, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Molecular Oncology is a visually stunning,…mehr
Andere Kunden interessierten sich auch für
- Solomon, Isaac H., MD, PhD (Department of Pat Associate PathologistDiagnostic Pathology: Infectious Diseases300,99 €
- Dylan V. Miller (MD Professor Dylan V. Miller (Clinical) DepartmenDiagnostic Pathology: Hospital Autopsy309,99 €
- Angelica R. Putnam (University of Associate Professor of PathologyDiagnostic Pathology: Pediatric Neoplasms388,99 €
- L. Jeffrey Medeiros (Professor and Department of Hematopatho ChairDiagnostic Pathology: Lymph Nodes and Extranodal Lymphomas306,99 €
- Marisa R. Nucci (Vice Chair and Women's Director and Perinatal PatDiagnostic Pathology: Gynecological226,99 €
- Robert B. Colvin (Benjamin Castleman Distinguished Professor of PatDiagnostic Pathology: Kidney Diseases249,99 €
- Aaron Auerbach (Senior Hematopathologist, Joint Pathology Center, SDiagnostic Pathology: Spleen316,99 €
-
-
-
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Providing a clear understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer in an era of personalized medicine, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Molecular Oncology is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, molecular pathologist, oncologist, or pathologist in training as an ideal day-to-day reference or as a reliable learning resource. * Provides up-to-date, comprehensive coverage of relevant molecular tests and their clinical applications, along with organ-based chapters on the molecular genetic data relevant to individual disease entities * Contains new chapters and substantial revisions to existing content that include updates from the 2022 International Consensus Classification and the WHO Classification of Haematolymphoid Tumours , fifth edition * Provides expert guidance on selecting the right test(s) at the right time, as well as comparisons of molecular testing methods (e.g., FISH vs. cytogenetics) * Includes current information for new actionable mutations and targeted therapies * Covers ultrasensitive molecular techniques for minimal residual disease detection and disease monitoring * Discusses circulating cell-free DNA analysis for detection of resistance-associated mutations and disease monitoring, and provides usage details * Features an image-rich layout with more than 2,400 print and online-only images, including high-resolution H&E stains, immunostains, FISH images, gross pathology and clinical photographs, detailed full-color medical illustrations, and informative diagrams, charts, and schematics * Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care * Includes an eBook version that enables you to access all text, figures, and references with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Produktdetails
- Produktdetails
- Diagnostic Pathology
- Verlag: Elsevier Health Sciences
- 3 ed
- Seitenzahl: 1048
- Erscheinungstermin: 19. Dezember 2023
- Englisch
- Abmessung: 281mm x 227mm x 48mm
- Gewicht: 3084g
- ISBN-13: 9780443112201
- ISBN-10: 0443112207
- Artikelnr.: 67608387
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- gpsr@libri.de
- Diagnostic Pathology
- Verlag: Elsevier Health Sciences
- 3 ed
- Seitenzahl: 1048
- Erscheinungstermin: 19. Dezember 2023
- Englisch
- Abmessung: 281mm x 227mm x 48mm
- Gewicht: 3084g
- ISBN-13: 9780443112201
- ISBN-10: 0443112207
- Artikelnr.: 67608387
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- gpsr@libri.de
Mohammad A. Vasef, MD, is a Professor at the Department of Pathology and Director of MGP Fellowship Program at The University of New Mexico Health Sciences Center. He is also Medical Director of Molecular Diagnostics, and works for TriCore Reference Laboratories in Albuquerque, New Mexico.
SECTION 1: INTRODUCTION 4 Structure of Chromosomes and Nucleic Acids Jeremy C. Wallentine
MD 8 DNA Replication
Transcription
and Translation Jeremy C. Wallentine
MD 12 Gene Mutations Jeremy C. Wallentine
MD SECTION 2: COMMON TECHNIQUES FOR ANALYSIS OF ALTERATIONS IN CHROMOSOMES AND DNA 18 Cytogenetics and FISH Mohammad A. Vasef
MD and David R. Czuchlewski
MD 22 Chromosomal Microarray Mohammad A. Vasef
MD and Sibel Kantarci
PhD 26 Amplification Methods Devon Chabot-Richards
MD 30 DNA High-Resolution Melting Curve Analysis Amer Mahmoud
MD
FCAP 32 Sequencing Technologies Eric Y. Loo
MD and Mohammad A. Vasef
MD 36 High-Throughput Methods in Molecular Pathology Rama Gullapalli
MD
PhD 38 DNA Methylation Analysis Devon Chabot-Richards
MD SECTION 3: MOLECULAR GENETIC TESTS IN HEMATOPOIETIC TUMORS 42 BCR::ABL1 Fusion Eric Y. Loo
MD and Mohammad A. Vasef
MD 46 PML::RARA Fusion Devon Chabot-Richards
MD 48 Reverse Transcription PCR for Myeloid Leukemia Transcripts Kristin Hunt Karner
MD 50 FLT3
NPM1
and CEBPA Mutations Devon Chabot-Richards
MD 54 JAK2 Mutations and Rearrangements Mohammad A. Vasef
MD 56 MPL Mutations Eric Y. Loo
MD and David R. Czuchlewski
MD 58 Calreticulin (CALR) Mutations Eric Y. Loo
MD and Mohammad A. Vasef
MD 60 CSF3R Mutations Amer Mahmoud
MD
FCAP 62 SETBP1 Mutations Amer Mahmoud
MD
FCAP 64 KIT Mutations Eric Y. Loo
MD and Mohammad A. Vasef
MD 68 IDH1 and IDH2 Mutations Eric Y. Loo
MD and David R. Czuchlewski
MD 70 Other Mutations and Gene Panel Testing in Myeloid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD 72 Immunoglobulin Heavy (IGH) Chain Gene Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 76 T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 80 T-Cell Receptor Beta (TRB) Chain Gene Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 84 Southern Blot Analysis of Antigen Receptor Genes Mohammad A. Vasef
MD 86 EBV-Associated Human Neoplasms Mohammad A. Vasef
MD 94 MYD88 Mutation Giovanni Insuasti-Beltran
MD 96 NOTCH1 Mutation Giovanni Insuasti-Beltran
MD 98 EZH2 Mutation Amer Mahmoud
MD
FCAP SECTION 4: MOLECULAR GENETIC TESTS IN SOLID TUMORS
BONE AND SOFT TISSUE TUMORS
AND CNS TUMORS 104 ALK Rearrangements and Mutations Guanghua Wang
MD 106 ROS1 Rearrangements Mohammad A. Vasef
MD and David R. Czuchlewski
MD 108 RET Rearrangements Eric Y. Loo
MD and David R. Czuchlewski
MD 110 FISH for MET Amplifications Devon Chabot-Richards
MD 114 FISH for ERBB2 (HER2) Amplifications M. Carmen Frias Kletecka
MD and Kristin Hunt Karner
MD 116 KRAS Mutations Guanghua Wang
MD 118 BRAF Mutations Yongjie Zhou
MD
PhD and Guanghua Wang
MD 120 EGFR Mutations Guanghua Wang
MD 122 Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next-Generation Sequencing) Mohammad A. Vasef
MD and David R. Czuchlewski
MD 124 Targeted Hotspot Gene Panel Table Mohammad A. Vasef
MD and David R. Czuchlewski
MD 130 MGMT Promoter Gene Methylation Assay Devon Chabot-Richards
MD SECTION 5: MOLECULAR PATHOLOGY OF MYELOID NEOPLASMS 134 Molecular Work-Up of Myeloid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD MYELOPROLIFERATIVE NEOPLASMS 136 Chronic Myeloid Leukemia
BCR::ABL1-Positive Mohammad A. Vasef
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 144 Chronic Neutrophilic Leukemia Devon Chabot-Richards
MD and David R. Czuchlewski
MD 148 Polycythemia Vera Mohammad A. Vasef
MD and M. Carmen Frias Kletecka
MD 152 Primary Myelofibrosis Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD 156 Essential Thrombocythemia Giovanni Insuasti-Beltran
MD 160 Chronic Eosinophilic Leukemia
NOS Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD 162 Myeloproliferative Neoplasm
Unclassifiable Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD MASTOCYTOSIS 166 Mastocytosis Mohammad A. Vasef
MD MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND GENE REARRANGEMENT 174 Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions Devon Chabot-Richards
MD and David R. Czuchlewski
MD PREMALIGNANT CLONAL HEMATOPOIESIS AND CYTOPENIAS 178 VEXAS Syndrome Mohammad A. Vasef
MD and Michael M. Franklin
DO 182 Clonal Hematopoiesis and Premalignant Clonal Cytopenia Mohammad A. Vasef
MD MYELODYSPLASTIC SYNDROME (MDS) 184 Overview and Classification of Myelodysplastic Syndrome Devon Chabot-Richards
MD
David R. Czuchlewski
MD
and Carla S. Wilson
MD
PhD 188 Myelodysplastic Syndrome With Mutated SF3B1 Mohammad A. Vasef
MD and Carla S. Wilson
MD
PhD 192 Myelodysplastic Syndrome
NOS Kristin Hunt Karner
MD 200 Myelodysplastic Syndrome With del(5q) Giovanni Insuasti-Beltran
MD 204 Myelodysplastic Syndrome With TP53 Multihit Mutations Kristin Hunt Karner
MD 206 Myelodysplastic Syndrome/Acute Myeloid Leukemia Kristin Hunt Karner
MD 208 Pediatric Myelodysplastic Syndrome and Refractory Cytopenia of Childhood Devon Chabot-Richards
MD and Carla S. Wilson
MD
PhD MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS 214 Overview of Myelodysplastic/Myeloproliferative Neoplasms Devon Chabot-Richards
MD 216 Chronic Myelomonocytic Leukemia Kristin Hunt Karner
MD 220 Atypical Chronic Myeloid Leukemia Devon Chabot-Richards
MD 224 Juvenile Myelomonocytic Leukemia Devon Chabot-Richards
MD and Qian-Yun Zhang
MD
PhD 228 Myelodysplastic/Myeloproliferative Neoplasm
NOS Devon Chabot-Richards
MD and Kathryn Foucar
MD ACUTE MYELOID LEUKEMIA 232 Overview of Acute Myeloid Leukemia Mohammad A. Vasef
MD and Kaaren K. Reichard
MD 240 Acute Myeloid Leukemia With t(8;21)/RUNX1::RUNX1T1 Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 244 Acute Myeloid Leukemia With inv(16) or t(16;16)/CBFB::MYH11 Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 248 Acute Promyelocytic Leukemia With t(15;17)/PML::RARA Mohammad A. Vasef
MD 254 Acute Myeloid Leukemia With t(9;11)/MLLT3::KMT2A Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 258 Acute Myeloid Leukemia With t(6:9)/DEK::NUP214 Eric Y. Loo
MD and David R. Czuchlewski
MD 260 Acute Myeloid Leukemia With inv(3) or t(3;3)/GATA2; MECOM Eric Y. Loo
MD and David R. Czuchlewski
MD 262 Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)/RBM15::MRTFA Eric Y. Loo
MD and David R. Czuchlewski
MD 264 Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities Kathryn Foucar
MD and Mohammad A. Vasef
MD 270 Acute Myeloid Leukemia
NOS Kristin Hunt Karner
MD 276 Myeloid Sarcoma Devon Chabot-Richards
MD 280 Myeloid Proliferations Associated With Down Syndrome Eric Y. Loo
MD and David R. Czuchlewski
MD BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM 284 Blastic Plasmacytoid Dendritic Cell Neoplasm Mohammad A. Vasef
MD SECTION 6: MOLECULAR PATHOLOGY OF LYMPHOID NEOPLASMS 292 Overview of Lymphoid Neoplasms Nadine Aguilera
MD 296 Molecular Work-Up of Lymphoid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD DETERMINATION OF CLONALITY IN B-
T-
AND NK-CELL NEOPLASMS 298 Lymphoma-Associated Chromosomal Translocations Kristin Hunt Karner
MD PRECURSOR LYMPHOID NEOPLASMS 302 B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities Kristin Hunt Karner
MD 306 B-Lymphoblastic Leukemia/Lymphoma
BCR::ABL1-Like (Ph-Like ALL) Joanna L. Conant
MD and Mohammad A. Vasef
MD 310 T-Lymphoblastic Leukemia/Lymphoma Mohammad A. Vasef
MD MATURE B-CELL NEOPLASMS 316 Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia Devon Chabot-Richards
MD 322 B-Cell Prolymphocytic Leukemia Aaron Auerbach
MD
MPH 326 Splenic Marginal Zone Lymphoma Aaron Auerbach
MD
MPH and Roberto N. Miranda
MD 332 Hairy Cell Leukemia Mohammad A. Vasef
MD 336 Splenic B-Cell Lymphoma/Leukemia
Unclassifiable Nadine Aguilera
MD 344 Lymphoplasmacytic Lymphoma Aaron Auerbach
MD
MPH 350 Monoclonal Gammopathy of Undetermined Significance Nadine Aguilera
MD 354 Multiple Myeloma (Plasma Cell Myeloma) Nadine Aguilera
MD and Carla S. Wilson
MD
PhD 362 Follicular Lymphoma Aaron Auerbach
MD
MPH
C. Cameron Yin
MD
PhD
and John Schmieg
MD
PhD 370 Mantle Cell Lymphoma Aaron Auerbach
MD
MPH 376 Diffuse Large B-Cell Lymphoma Nadine Aguilera
MD 386 Burkitt Lymphoma Aaron Auerbach
MD
MPH and Carlos Bueso-Ramos
MD
PhD MATURE T- AND NK-CELL NEOPLASMS 394 T-Cell Prolymphocytic Leukemia Nadine Aguilera
MD 398 Chronic Lymphoproliferative Disorder of NK Cells Nadine Aguilera
MD 402 Aggressive NK-Cell Leukemia Nadine Aguilera
MD 406 Extranodal NK-/T-Cell Lymphoma Aaron Auerbach
MD
MPH and L. Jeffrey Medeiros
MD 410 Adult T-Cell Leukemia/Lymphoma Nadine Aguilera
MD 416 Intestinal T-Cell Lymphoma Aaron Auerbach
MD
MPH and Sa A. Wang
MD 424 Hepatosplenic T-Cell Lymphoma Aaron Auerbach
MD
MPH and Roberto N. Miranda
MD 428 Subcutaneous Panniculitis-Like T-Cell Lymphoma Aaron Auerbach
MD
MPH 432 Mycosis Fungoides/Sézary Syndrome Aaron Auerbach
MD
MPH and Sa A. Wang
MD 438 Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders Aaron Auerbach
MD
MPH 442 Peripheral T-Cell Lymphoma
NOS Aaron Auerbach
MD
MPH 448 Nodal Follicular Helper T-Cell Lymphoma Aaron Auerbach
MD
MPH 456 Anaplastic Large Cell Lymphoma
ALK-Negative Mohammad A. Vasef
MD 462 Anaplastic Large Cell Lymphoma
ALK-Positive Mohammad A. Vasef
MD SECTION 7: MOLECULAR PATHOLOGY OF DENDRITIC CELL AND HISTIOCYTIC NEOPLASMS 470 Histiocytic Sarcoma Nadine Aguilera
MD 478 Langerhans Cell Histiocytosis Guanghua Wang
MD 484 Interdigitating Dendritic Cell Sarcoma Aaron Auerbach
MD
MPH and Sa A. Wang
MD 488 Follicular Dendritic Cell Sarcoma Aaron Auerbach
MD
MPH SECTION 8: MOLECULAR PATHOLOGY OF SOLID TUMORS HEAD AND NECK
INCLUDING SINONASAL TUMORS AND SALIVARY GLANDS 494 HPV-Associated Head and Neck Carcinomas Thèrése Bocklage
MD 500 Head and Neck Mucosal Squamous Cell Carcinoma
Non-HPV Related Thèrése Bocklage
MD 506 Important Alterations in Non-HPV-Related Head and Neck Squamous Cell Carcinoma Thèrése Bocklage
MD 508 Translocation-Specific Salivary Gland Tumors Thèrése Bocklage
MD 518 Translocation-Specific Salivary Gland Tumors (Continued) Thèrése Bocklage
MD 526 Nasopharyngeal EBV-Related Squamous Cell Carcinoma Thèrése Bocklage
MD 530 Other Head and Neck Tumors Thèrése Bocklage
MD THYROID 538 Papillary Thyroid Carcinoma Giovanni Insuasti-Beltran
MD 542 Follicular Thyroid Carcinoma Giovanni Insuasti-Beltran
MD 546 Poorly Differentiated Thyroid Carcinoma Von Samedi
MD
PhD 550 Anaplastic Thyroid Carcinoma Von Samedi
MD
PhD 554 Medullary Thyroid Carcinoma Giovanni Insuasti-Beltran
MD LUNG 560 Adenocarcinoma
Lung Jeremy C. Wallentine
MD 568 Squamous Cell Carcinoma
Lung Jeremy C. Wallentine
MD 572 Small Cell Neuroendocrine Carcinoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 576 Mesothelioma Mohammad A. Vasef
MD and Khalil Sheibani
MD
FCAP LUMINAL GASTROINTESTINAL TRACT 580 Gastric Adenocarcinoma M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD 584 Colorectal Adenocarcinoma and Precancerous Lesions M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD 590 Gastrointestinal Stromal Tumor M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD LIVER 598 HNF1A-Inactivated Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 602 ß-Catenin-Activated Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 606 Inflammatory Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 610 Hepatocellular Carcinoma Rama Gullapalli
MD
PhD PANCREATICOBILIARY 614 Pancreatic Ductal Adenocarcinoma Von Samedi
MD
PhD 618 Pancreatic Mucinous Cystic Neoplasm Von Samedi
MD
PhD 620 Pancreatic Intraductal Papillary Mucinous Neoplasm Von Samedi
MD
PhD 622 Cholangiocarcinoma Rama Gullapalli
MD
PhD TESTIS 624 Testicular Germ Cell Tumors Edgar Fischer
MD
PhD KIDNEY 630 Clear Cell Renal Cell Carcinoma Edgar Fischer
MD
PhD 634 Chromophobe Renal Cell Carcinoma Edgar Fischer
MD
PhD 636 Papillary Renal Cell Carcinoma Edgar Fischer
MD
PhD 638 TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas Edgar Fischer
MD
PhD 642 Wilms Tumor Marc Barry
MD 648 Clear Cell Sarcoma of Kidney Marc Barry
MD 650 Oncocytoma Marc Barry
MD 652 Rhabdoid Tumor of Kidney Marc Barry
MD BLADDER 654 Urothelial Carcinoma Marc Barry
MD ADRENAL 660 Pheochromocytoma/Paraganglioma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 666 Adrenal Cortical Carcinoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 672 Neuroblastoma Giovanni Insuasti-Beltran
MD
Thèrése Bocklage
MD
and Samuel Reynolds
MD 680 Adrenal Cortical Adenoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD PROSTATE 684 Prostatic Adenocarcinoma
Acinar Type and High-Grade Prostatic Intraepithelial Neoplasia Edgar Fischer
MD
PhD BREAST 688 ADH and DCIS (Dysplastic
Premalignant) David G. Hicks
MD 694 Ductal Carcinomas David G. Hicks
MD 700 Lobular Carcinoma David G. Hicks
MD 706 Invasive Ductal Carcinoma of No Special Type With Medullary Features Rania Bakkar
MD 710 Metaplastic Breast Carcinoma Rania Bakkar
MD 716 Phyllodes Tumors Rania Bakkar
MD 720 Basal-Like and Triple-Negative Breast Carcinomas David G. Hicks
MD and Susan C. Lester
MD
PhD CERVIX/VULVA/VAGINA 730 Preneoplastic Conditions
Cervix/Vulva/Vagina Nancy Joste
MD 734 Squamous Cell Carcinoma
Cervix/Vulva/Vagina Nancy Joste
MD 738 Adenocarcinoma
Cervix/Vulva/Vagina Nancy Joste
MD UTERUS 742 Endometrial Intraepithelial Neoplasia Lesley Lomo
MD 744 Uterine Endometrioid Carcinoma Lesley Lomo
MD 748 Uterine Serous Carcinoma Lesley Lomo
MD 750 Clear Cell Carcinoma
Uterus Lesley Lomo
MD 754 Uterine Sarcomas Thèrése Bocklage
MD OVARIES/FALLOPIAN TUBE 762 Serous Tumors of Ovary and Fallopian Tube Rania Bakkar
MD 768 Other Surface Epithelial Tumors of Ovary Rania Bakkar
MD 774 Sex Cord-Stromal Tumors of Ovary Rania Bakkar
MD 780 Germ Cell Tumor
Ovary Rania Bakkar
MD and Aaron Auerbach
MD
MPH SKIN 784 Premalignant Conditions
Skin David Cassarino
MD
PhD 788 Melanoma David Cassarino
MD
PhD 792 Squamous Cell Carcinoma
Skin David Cassarino
MD
PhD 796 Basal Cell Carcinoma
Skin David Cassarino
MD
PhD 800 Sebaceous Tumors David Cassarino
MD
PhD 802 Dermatofibroma and Dermatofibrosarcoma Protuberans David Cassarino
MD
PhD BONE 804 Overview of Molecular Pathology of Bone and Soft Tissue Tumors Thèrése Bocklage
MD 810 Osteosarcomas Thèrése Bocklage
MD 818 Ewing Sarcoma Thèrése Bocklage
MD 824 Other Small Round Blue Cell Sarcomas Thèrése Bocklage
MD 832 Giant Cell Tumor of Bone Thèrése Bocklage
MD 838 Intermediate and Malignant Cartilaginous Tumors of Bone Thèrése Bocklage
MD SOFT TISSUE 848 Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors Thèrése Bocklage
MD 858 Liposarcomas Thèrése Bocklage
MD 868 Muscle Sarcomas Thèrése Bocklage
MD 878 Intermediate and Malignant Vascular Tumors Thèrése Bocklage
MD 886 Malignant Peripheral Nerve Sheath Tumor Thèrése Bocklage
MD and David R. Lucas
MD 892 Representative Genetic Findings in Bone and Soft Tissue Tumors Thèrése Bocklage
MD SARCOMAS OF UNCERTAIN DIFFERENTIATION 898 Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations Thèrése Bocklage
MD 908 Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations (Continued) Thèrése Bocklage
MD CNS 916 Glioblastoma
IDH Wildtype Elisabeth Rushing
MD and Mohammad A. Vasef
MD 920 Astrocytoma
IDH-Mutant Elisabeth Rushing
MD and Mohammad A. Vasef
MD 924 Pilocytic Astrocytoma Aaron Auerbach
MD
MPH
Karen SantaCruz
MD
and Elisabeth Rushing
MD 928 Oligodendroglioma
IDH Mutant
and 1p/19q Codeleted Aaron Auerbach
MD
MPH
Karen SantaCruz
MD
and Elisabeth Rushing
MD 932 Ependymal Tumors Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 938 Medulloblastoma Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 944 Choroid Plexus Tumors Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 948 Meningioma Mohammad A. Vasef
MD and Karen SantaCruz
MD 952 Retinoblastoma Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD SECTION 9: QUALITY ASSURANCE AND REGULATORY ISSUES 958 Federal Agencies and Regulation of Laboratories Amer Mahmoud
MD
FCAP 960 FDA Regulations Yongjie Zhou
MD
PhD 966 Proficiency Testing and Accreditation Amer Mahmoud
MD
FCAP
MD 8 DNA Replication
Transcription
and Translation Jeremy C. Wallentine
MD 12 Gene Mutations Jeremy C. Wallentine
MD SECTION 2: COMMON TECHNIQUES FOR ANALYSIS OF ALTERATIONS IN CHROMOSOMES AND DNA 18 Cytogenetics and FISH Mohammad A. Vasef
MD and David R. Czuchlewski
MD 22 Chromosomal Microarray Mohammad A. Vasef
MD and Sibel Kantarci
PhD 26 Amplification Methods Devon Chabot-Richards
MD 30 DNA High-Resolution Melting Curve Analysis Amer Mahmoud
MD
FCAP 32 Sequencing Technologies Eric Y. Loo
MD and Mohammad A. Vasef
MD 36 High-Throughput Methods in Molecular Pathology Rama Gullapalli
MD
PhD 38 DNA Methylation Analysis Devon Chabot-Richards
MD SECTION 3: MOLECULAR GENETIC TESTS IN HEMATOPOIETIC TUMORS 42 BCR::ABL1 Fusion Eric Y. Loo
MD and Mohammad A. Vasef
MD 46 PML::RARA Fusion Devon Chabot-Richards
MD 48 Reverse Transcription PCR for Myeloid Leukemia Transcripts Kristin Hunt Karner
MD 50 FLT3
NPM1
and CEBPA Mutations Devon Chabot-Richards
MD 54 JAK2 Mutations and Rearrangements Mohammad A. Vasef
MD 56 MPL Mutations Eric Y. Loo
MD and David R. Czuchlewski
MD 58 Calreticulin (CALR) Mutations Eric Y. Loo
MD and Mohammad A. Vasef
MD 60 CSF3R Mutations Amer Mahmoud
MD
FCAP 62 SETBP1 Mutations Amer Mahmoud
MD
FCAP 64 KIT Mutations Eric Y. Loo
MD and Mohammad A. Vasef
MD 68 IDH1 and IDH2 Mutations Eric Y. Loo
MD and David R. Czuchlewski
MD 70 Other Mutations and Gene Panel Testing in Myeloid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD 72 Immunoglobulin Heavy (IGH) Chain Gene Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 76 T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 80 T-Cell Receptor Beta (TRB) Chain Gene Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 84 Southern Blot Analysis of Antigen Receptor Genes Mohammad A. Vasef
MD 86 EBV-Associated Human Neoplasms Mohammad A. Vasef
MD 94 MYD88 Mutation Giovanni Insuasti-Beltran
MD 96 NOTCH1 Mutation Giovanni Insuasti-Beltran
MD 98 EZH2 Mutation Amer Mahmoud
MD
FCAP SECTION 4: MOLECULAR GENETIC TESTS IN SOLID TUMORS
BONE AND SOFT TISSUE TUMORS
AND CNS TUMORS 104 ALK Rearrangements and Mutations Guanghua Wang
MD 106 ROS1 Rearrangements Mohammad A. Vasef
MD and David R. Czuchlewski
MD 108 RET Rearrangements Eric Y. Loo
MD and David R. Czuchlewski
MD 110 FISH for MET Amplifications Devon Chabot-Richards
MD 114 FISH for ERBB2 (HER2) Amplifications M. Carmen Frias Kletecka
MD and Kristin Hunt Karner
MD 116 KRAS Mutations Guanghua Wang
MD 118 BRAF Mutations Yongjie Zhou
MD
PhD and Guanghua Wang
MD 120 EGFR Mutations Guanghua Wang
MD 122 Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next-Generation Sequencing) Mohammad A. Vasef
MD and David R. Czuchlewski
MD 124 Targeted Hotspot Gene Panel Table Mohammad A. Vasef
MD and David R. Czuchlewski
MD 130 MGMT Promoter Gene Methylation Assay Devon Chabot-Richards
MD SECTION 5: MOLECULAR PATHOLOGY OF MYELOID NEOPLASMS 134 Molecular Work-Up of Myeloid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD MYELOPROLIFERATIVE NEOPLASMS 136 Chronic Myeloid Leukemia
BCR::ABL1-Positive Mohammad A. Vasef
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 144 Chronic Neutrophilic Leukemia Devon Chabot-Richards
MD and David R. Czuchlewski
MD 148 Polycythemia Vera Mohammad A. Vasef
MD and M. Carmen Frias Kletecka
MD 152 Primary Myelofibrosis Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD 156 Essential Thrombocythemia Giovanni Insuasti-Beltran
MD 160 Chronic Eosinophilic Leukemia
NOS Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD 162 Myeloproliferative Neoplasm
Unclassifiable Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD MASTOCYTOSIS 166 Mastocytosis Mohammad A. Vasef
MD MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND GENE REARRANGEMENT 174 Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions Devon Chabot-Richards
MD and David R. Czuchlewski
MD PREMALIGNANT CLONAL HEMATOPOIESIS AND CYTOPENIAS 178 VEXAS Syndrome Mohammad A. Vasef
MD and Michael M. Franklin
DO 182 Clonal Hematopoiesis and Premalignant Clonal Cytopenia Mohammad A. Vasef
MD MYELODYSPLASTIC SYNDROME (MDS) 184 Overview and Classification of Myelodysplastic Syndrome Devon Chabot-Richards
MD
David R. Czuchlewski
MD
and Carla S. Wilson
MD
PhD 188 Myelodysplastic Syndrome With Mutated SF3B1 Mohammad A. Vasef
MD and Carla S. Wilson
MD
PhD 192 Myelodysplastic Syndrome
NOS Kristin Hunt Karner
MD 200 Myelodysplastic Syndrome With del(5q) Giovanni Insuasti-Beltran
MD 204 Myelodysplastic Syndrome With TP53 Multihit Mutations Kristin Hunt Karner
MD 206 Myelodysplastic Syndrome/Acute Myeloid Leukemia Kristin Hunt Karner
MD 208 Pediatric Myelodysplastic Syndrome and Refractory Cytopenia of Childhood Devon Chabot-Richards
MD and Carla S. Wilson
MD
PhD MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS 214 Overview of Myelodysplastic/Myeloproliferative Neoplasms Devon Chabot-Richards
MD 216 Chronic Myelomonocytic Leukemia Kristin Hunt Karner
MD 220 Atypical Chronic Myeloid Leukemia Devon Chabot-Richards
MD 224 Juvenile Myelomonocytic Leukemia Devon Chabot-Richards
MD and Qian-Yun Zhang
MD
PhD 228 Myelodysplastic/Myeloproliferative Neoplasm
NOS Devon Chabot-Richards
MD and Kathryn Foucar
MD ACUTE MYELOID LEUKEMIA 232 Overview of Acute Myeloid Leukemia Mohammad A. Vasef
MD and Kaaren K. Reichard
MD 240 Acute Myeloid Leukemia With t(8;21)/RUNX1::RUNX1T1 Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 244 Acute Myeloid Leukemia With inv(16) or t(16;16)/CBFB::MYH11 Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 248 Acute Promyelocytic Leukemia With t(15;17)/PML::RARA Mohammad A. Vasef
MD 254 Acute Myeloid Leukemia With t(9;11)/MLLT3::KMT2A Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 258 Acute Myeloid Leukemia With t(6:9)/DEK::NUP214 Eric Y. Loo
MD and David R. Czuchlewski
MD 260 Acute Myeloid Leukemia With inv(3) or t(3;3)/GATA2; MECOM Eric Y. Loo
MD and David R. Czuchlewski
MD 262 Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)/RBM15::MRTFA Eric Y. Loo
MD and David R. Czuchlewski
MD 264 Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities Kathryn Foucar
MD and Mohammad A. Vasef
MD 270 Acute Myeloid Leukemia
NOS Kristin Hunt Karner
MD 276 Myeloid Sarcoma Devon Chabot-Richards
MD 280 Myeloid Proliferations Associated With Down Syndrome Eric Y. Loo
MD and David R. Czuchlewski
MD BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM 284 Blastic Plasmacytoid Dendritic Cell Neoplasm Mohammad A. Vasef
MD SECTION 6: MOLECULAR PATHOLOGY OF LYMPHOID NEOPLASMS 292 Overview of Lymphoid Neoplasms Nadine Aguilera
MD 296 Molecular Work-Up of Lymphoid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD DETERMINATION OF CLONALITY IN B-
T-
AND NK-CELL NEOPLASMS 298 Lymphoma-Associated Chromosomal Translocations Kristin Hunt Karner
MD PRECURSOR LYMPHOID NEOPLASMS 302 B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities Kristin Hunt Karner
MD 306 B-Lymphoblastic Leukemia/Lymphoma
BCR::ABL1-Like (Ph-Like ALL) Joanna L. Conant
MD and Mohammad A. Vasef
MD 310 T-Lymphoblastic Leukemia/Lymphoma Mohammad A. Vasef
MD MATURE B-CELL NEOPLASMS 316 Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia Devon Chabot-Richards
MD 322 B-Cell Prolymphocytic Leukemia Aaron Auerbach
MD
MPH 326 Splenic Marginal Zone Lymphoma Aaron Auerbach
MD
MPH and Roberto N. Miranda
MD 332 Hairy Cell Leukemia Mohammad A. Vasef
MD 336 Splenic B-Cell Lymphoma/Leukemia
Unclassifiable Nadine Aguilera
MD 344 Lymphoplasmacytic Lymphoma Aaron Auerbach
MD
MPH 350 Monoclonal Gammopathy of Undetermined Significance Nadine Aguilera
MD 354 Multiple Myeloma (Plasma Cell Myeloma) Nadine Aguilera
MD and Carla S. Wilson
MD
PhD 362 Follicular Lymphoma Aaron Auerbach
MD
MPH
C. Cameron Yin
MD
PhD
and John Schmieg
MD
PhD 370 Mantle Cell Lymphoma Aaron Auerbach
MD
MPH 376 Diffuse Large B-Cell Lymphoma Nadine Aguilera
MD 386 Burkitt Lymphoma Aaron Auerbach
MD
MPH and Carlos Bueso-Ramos
MD
PhD MATURE T- AND NK-CELL NEOPLASMS 394 T-Cell Prolymphocytic Leukemia Nadine Aguilera
MD 398 Chronic Lymphoproliferative Disorder of NK Cells Nadine Aguilera
MD 402 Aggressive NK-Cell Leukemia Nadine Aguilera
MD 406 Extranodal NK-/T-Cell Lymphoma Aaron Auerbach
MD
MPH and L. Jeffrey Medeiros
MD 410 Adult T-Cell Leukemia/Lymphoma Nadine Aguilera
MD 416 Intestinal T-Cell Lymphoma Aaron Auerbach
MD
MPH and Sa A. Wang
MD 424 Hepatosplenic T-Cell Lymphoma Aaron Auerbach
MD
MPH and Roberto N. Miranda
MD 428 Subcutaneous Panniculitis-Like T-Cell Lymphoma Aaron Auerbach
MD
MPH 432 Mycosis Fungoides/Sézary Syndrome Aaron Auerbach
MD
MPH and Sa A. Wang
MD 438 Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders Aaron Auerbach
MD
MPH 442 Peripheral T-Cell Lymphoma
NOS Aaron Auerbach
MD
MPH 448 Nodal Follicular Helper T-Cell Lymphoma Aaron Auerbach
MD
MPH 456 Anaplastic Large Cell Lymphoma
ALK-Negative Mohammad A. Vasef
MD 462 Anaplastic Large Cell Lymphoma
ALK-Positive Mohammad A. Vasef
MD SECTION 7: MOLECULAR PATHOLOGY OF DENDRITIC CELL AND HISTIOCYTIC NEOPLASMS 470 Histiocytic Sarcoma Nadine Aguilera
MD 478 Langerhans Cell Histiocytosis Guanghua Wang
MD 484 Interdigitating Dendritic Cell Sarcoma Aaron Auerbach
MD
MPH and Sa A. Wang
MD 488 Follicular Dendritic Cell Sarcoma Aaron Auerbach
MD
MPH SECTION 8: MOLECULAR PATHOLOGY OF SOLID TUMORS HEAD AND NECK
INCLUDING SINONASAL TUMORS AND SALIVARY GLANDS 494 HPV-Associated Head and Neck Carcinomas Thèrése Bocklage
MD 500 Head and Neck Mucosal Squamous Cell Carcinoma
Non-HPV Related Thèrése Bocklage
MD 506 Important Alterations in Non-HPV-Related Head and Neck Squamous Cell Carcinoma Thèrése Bocklage
MD 508 Translocation-Specific Salivary Gland Tumors Thèrése Bocklage
MD 518 Translocation-Specific Salivary Gland Tumors (Continued) Thèrése Bocklage
MD 526 Nasopharyngeal EBV-Related Squamous Cell Carcinoma Thèrése Bocklage
MD 530 Other Head and Neck Tumors Thèrése Bocklage
MD THYROID 538 Papillary Thyroid Carcinoma Giovanni Insuasti-Beltran
MD 542 Follicular Thyroid Carcinoma Giovanni Insuasti-Beltran
MD 546 Poorly Differentiated Thyroid Carcinoma Von Samedi
MD
PhD 550 Anaplastic Thyroid Carcinoma Von Samedi
MD
PhD 554 Medullary Thyroid Carcinoma Giovanni Insuasti-Beltran
MD LUNG 560 Adenocarcinoma
Lung Jeremy C. Wallentine
MD 568 Squamous Cell Carcinoma
Lung Jeremy C. Wallentine
MD 572 Small Cell Neuroendocrine Carcinoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 576 Mesothelioma Mohammad A. Vasef
MD and Khalil Sheibani
MD
FCAP LUMINAL GASTROINTESTINAL TRACT 580 Gastric Adenocarcinoma M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD 584 Colorectal Adenocarcinoma and Precancerous Lesions M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD 590 Gastrointestinal Stromal Tumor M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD LIVER 598 HNF1A-Inactivated Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 602 ß-Catenin-Activated Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 606 Inflammatory Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 610 Hepatocellular Carcinoma Rama Gullapalli
MD
PhD PANCREATICOBILIARY 614 Pancreatic Ductal Adenocarcinoma Von Samedi
MD
PhD 618 Pancreatic Mucinous Cystic Neoplasm Von Samedi
MD
PhD 620 Pancreatic Intraductal Papillary Mucinous Neoplasm Von Samedi
MD
PhD 622 Cholangiocarcinoma Rama Gullapalli
MD
PhD TESTIS 624 Testicular Germ Cell Tumors Edgar Fischer
MD
PhD KIDNEY 630 Clear Cell Renal Cell Carcinoma Edgar Fischer
MD
PhD 634 Chromophobe Renal Cell Carcinoma Edgar Fischer
MD
PhD 636 Papillary Renal Cell Carcinoma Edgar Fischer
MD
PhD 638 TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas Edgar Fischer
MD
PhD 642 Wilms Tumor Marc Barry
MD 648 Clear Cell Sarcoma of Kidney Marc Barry
MD 650 Oncocytoma Marc Barry
MD 652 Rhabdoid Tumor of Kidney Marc Barry
MD BLADDER 654 Urothelial Carcinoma Marc Barry
MD ADRENAL 660 Pheochromocytoma/Paraganglioma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 666 Adrenal Cortical Carcinoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 672 Neuroblastoma Giovanni Insuasti-Beltran
MD
Thèrése Bocklage
MD
and Samuel Reynolds
MD 680 Adrenal Cortical Adenoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD PROSTATE 684 Prostatic Adenocarcinoma
Acinar Type and High-Grade Prostatic Intraepithelial Neoplasia Edgar Fischer
MD
PhD BREAST 688 ADH and DCIS (Dysplastic
Premalignant) David G. Hicks
MD 694 Ductal Carcinomas David G. Hicks
MD 700 Lobular Carcinoma David G. Hicks
MD 706 Invasive Ductal Carcinoma of No Special Type With Medullary Features Rania Bakkar
MD 710 Metaplastic Breast Carcinoma Rania Bakkar
MD 716 Phyllodes Tumors Rania Bakkar
MD 720 Basal-Like and Triple-Negative Breast Carcinomas David G. Hicks
MD and Susan C. Lester
MD
PhD CERVIX/VULVA/VAGINA 730 Preneoplastic Conditions
Cervix/Vulva/Vagina Nancy Joste
MD 734 Squamous Cell Carcinoma
Cervix/Vulva/Vagina Nancy Joste
MD 738 Adenocarcinoma
Cervix/Vulva/Vagina Nancy Joste
MD UTERUS 742 Endometrial Intraepithelial Neoplasia Lesley Lomo
MD 744 Uterine Endometrioid Carcinoma Lesley Lomo
MD 748 Uterine Serous Carcinoma Lesley Lomo
MD 750 Clear Cell Carcinoma
Uterus Lesley Lomo
MD 754 Uterine Sarcomas Thèrése Bocklage
MD OVARIES/FALLOPIAN TUBE 762 Serous Tumors of Ovary and Fallopian Tube Rania Bakkar
MD 768 Other Surface Epithelial Tumors of Ovary Rania Bakkar
MD 774 Sex Cord-Stromal Tumors of Ovary Rania Bakkar
MD 780 Germ Cell Tumor
Ovary Rania Bakkar
MD and Aaron Auerbach
MD
MPH SKIN 784 Premalignant Conditions
Skin David Cassarino
MD
PhD 788 Melanoma David Cassarino
MD
PhD 792 Squamous Cell Carcinoma
Skin David Cassarino
MD
PhD 796 Basal Cell Carcinoma
Skin David Cassarino
MD
PhD 800 Sebaceous Tumors David Cassarino
MD
PhD 802 Dermatofibroma and Dermatofibrosarcoma Protuberans David Cassarino
MD
PhD BONE 804 Overview of Molecular Pathology of Bone and Soft Tissue Tumors Thèrése Bocklage
MD 810 Osteosarcomas Thèrése Bocklage
MD 818 Ewing Sarcoma Thèrése Bocklage
MD 824 Other Small Round Blue Cell Sarcomas Thèrése Bocklage
MD 832 Giant Cell Tumor of Bone Thèrése Bocklage
MD 838 Intermediate and Malignant Cartilaginous Tumors of Bone Thèrése Bocklage
MD SOFT TISSUE 848 Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors Thèrése Bocklage
MD 858 Liposarcomas Thèrése Bocklage
MD 868 Muscle Sarcomas Thèrése Bocklage
MD 878 Intermediate and Malignant Vascular Tumors Thèrése Bocklage
MD 886 Malignant Peripheral Nerve Sheath Tumor Thèrése Bocklage
MD and David R. Lucas
MD 892 Representative Genetic Findings in Bone and Soft Tissue Tumors Thèrése Bocklage
MD SARCOMAS OF UNCERTAIN DIFFERENTIATION 898 Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations Thèrése Bocklage
MD 908 Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations (Continued) Thèrése Bocklage
MD CNS 916 Glioblastoma
IDH Wildtype Elisabeth Rushing
MD and Mohammad A. Vasef
MD 920 Astrocytoma
IDH-Mutant Elisabeth Rushing
MD and Mohammad A. Vasef
MD 924 Pilocytic Astrocytoma Aaron Auerbach
MD
MPH
Karen SantaCruz
MD
and Elisabeth Rushing
MD 928 Oligodendroglioma
IDH Mutant
and 1p/19q Codeleted Aaron Auerbach
MD
MPH
Karen SantaCruz
MD
and Elisabeth Rushing
MD 932 Ependymal Tumors Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 938 Medulloblastoma Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 944 Choroid Plexus Tumors Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 948 Meningioma Mohammad A. Vasef
MD and Karen SantaCruz
MD 952 Retinoblastoma Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD SECTION 9: QUALITY ASSURANCE AND REGULATORY ISSUES 958 Federal Agencies and Regulation of Laboratories Amer Mahmoud
MD
FCAP 960 FDA Regulations Yongjie Zhou
MD
PhD 966 Proficiency Testing and Accreditation Amer Mahmoud
MD
FCAP
SECTION 1: INTRODUCTION 4 Structure of Chromosomes and Nucleic Acids Jeremy C. Wallentine
MD 8 DNA Replication
Transcription
and Translation Jeremy C. Wallentine
MD 12 Gene Mutations Jeremy C. Wallentine
MD SECTION 2: COMMON TECHNIQUES FOR ANALYSIS OF ALTERATIONS IN CHROMOSOMES AND DNA 18 Cytogenetics and FISH Mohammad A. Vasef
MD and David R. Czuchlewski
MD 22 Chromosomal Microarray Mohammad A. Vasef
MD and Sibel Kantarci
PhD 26 Amplification Methods Devon Chabot-Richards
MD 30 DNA High-Resolution Melting Curve Analysis Amer Mahmoud
MD
FCAP 32 Sequencing Technologies Eric Y. Loo
MD and Mohammad A. Vasef
MD 36 High-Throughput Methods in Molecular Pathology Rama Gullapalli
MD
PhD 38 DNA Methylation Analysis Devon Chabot-Richards
MD SECTION 3: MOLECULAR GENETIC TESTS IN HEMATOPOIETIC TUMORS 42 BCR::ABL1 Fusion Eric Y. Loo
MD and Mohammad A. Vasef
MD 46 PML::RARA Fusion Devon Chabot-Richards
MD 48 Reverse Transcription PCR for Myeloid Leukemia Transcripts Kristin Hunt Karner
MD 50 FLT3
NPM1
and CEBPA Mutations Devon Chabot-Richards
MD 54 JAK2 Mutations and Rearrangements Mohammad A. Vasef
MD 56 MPL Mutations Eric Y. Loo
MD and David R. Czuchlewski
MD 58 Calreticulin (CALR) Mutations Eric Y. Loo
MD and Mohammad A. Vasef
MD 60 CSF3R Mutations Amer Mahmoud
MD
FCAP 62 SETBP1 Mutations Amer Mahmoud
MD
FCAP 64 KIT Mutations Eric Y. Loo
MD and Mohammad A. Vasef
MD 68 IDH1 and IDH2 Mutations Eric Y. Loo
MD and David R. Czuchlewski
MD 70 Other Mutations and Gene Panel Testing in Myeloid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD 72 Immunoglobulin Heavy (IGH) Chain Gene Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 76 T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 80 T-Cell Receptor Beta (TRB) Chain Gene Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 84 Southern Blot Analysis of Antigen Receptor Genes Mohammad A. Vasef
MD 86 EBV-Associated Human Neoplasms Mohammad A. Vasef
MD 94 MYD88 Mutation Giovanni Insuasti-Beltran
MD 96 NOTCH1 Mutation Giovanni Insuasti-Beltran
MD 98 EZH2 Mutation Amer Mahmoud
MD
FCAP SECTION 4: MOLECULAR GENETIC TESTS IN SOLID TUMORS
BONE AND SOFT TISSUE TUMORS
AND CNS TUMORS 104 ALK Rearrangements and Mutations Guanghua Wang
MD 106 ROS1 Rearrangements Mohammad A. Vasef
MD and David R. Czuchlewski
MD 108 RET Rearrangements Eric Y. Loo
MD and David R. Czuchlewski
MD 110 FISH for MET Amplifications Devon Chabot-Richards
MD 114 FISH for ERBB2 (HER2) Amplifications M. Carmen Frias Kletecka
MD and Kristin Hunt Karner
MD 116 KRAS Mutations Guanghua Wang
MD 118 BRAF Mutations Yongjie Zhou
MD
PhD and Guanghua Wang
MD 120 EGFR Mutations Guanghua Wang
MD 122 Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next-Generation Sequencing) Mohammad A. Vasef
MD and David R. Czuchlewski
MD 124 Targeted Hotspot Gene Panel Table Mohammad A. Vasef
MD and David R. Czuchlewski
MD 130 MGMT Promoter Gene Methylation Assay Devon Chabot-Richards
MD SECTION 5: MOLECULAR PATHOLOGY OF MYELOID NEOPLASMS 134 Molecular Work-Up of Myeloid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD MYELOPROLIFERATIVE NEOPLASMS 136 Chronic Myeloid Leukemia
BCR::ABL1-Positive Mohammad A. Vasef
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 144 Chronic Neutrophilic Leukemia Devon Chabot-Richards
MD and David R. Czuchlewski
MD 148 Polycythemia Vera Mohammad A. Vasef
MD and M. Carmen Frias Kletecka
MD 152 Primary Myelofibrosis Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD 156 Essential Thrombocythemia Giovanni Insuasti-Beltran
MD 160 Chronic Eosinophilic Leukemia
NOS Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD 162 Myeloproliferative Neoplasm
Unclassifiable Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD MASTOCYTOSIS 166 Mastocytosis Mohammad A. Vasef
MD MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND GENE REARRANGEMENT 174 Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions Devon Chabot-Richards
MD and David R. Czuchlewski
MD PREMALIGNANT CLONAL HEMATOPOIESIS AND CYTOPENIAS 178 VEXAS Syndrome Mohammad A. Vasef
MD and Michael M. Franklin
DO 182 Clonal Hematopoiesis and Premalignant Clonal Cytopenia Mohammad A. Vasef
MD MYELODYSPLASTIC SYNDROME (MDS) 184 Overview and Classification of Myelodysplastic Syndrome Devon Chabot-Richards
MD
David R. Czuchlewski
MD
and Carla S. Wilson
MD
PhD 188 Myelodysplastic Syndrome With Mutated SF3B1 Mohammad A. Vasef
MD and Carla S. Wilson
MD
PhD 192 Myelodysplastic Syndrome
NOS Kristin Hunt Karner
MD 200 Myelodysplastic Syndrome With del(5q) Giovanni Insuasti-Beltran
MD 204 Myelodysplastic Syndrome With TP53 Multihit Mutations Kristin Hunt Karner
MD 206 Myelodysplastic Syndrome/Acute Myeloid Leukemia Kristin Hunt Karner
MD 208 Pediatric Myelodysplastic Syndrome and Refractory Cytopenia of Childhood Devon Chabot-Richards
MD and Carla S. Wilson
MD
PhD MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS 214 Overview of Myelodysplastic/Myeloproliferative Neoplasms Devon Chabot-Richards
MD 216 Chronic Myelomonocytic Leukemia Kristin Hunt Karner
MD 220 Atypical Chronic Myeloid Leukemia Devon Chabot-Richards
MD 224 Juvenile Myelomonocytic Leukemia Devon Chabot-Richards
MD and Qian-Yun Zhang
MD
PhD 228 Myelodysplastic/Myeloproliferative Neoplasm
NOS Devon Chabot-Richards
MD and Kathryn Foucar
MD ACUTE MYELOID LEUKEMIA 232 Overview of Acute Myeloid Leukemia Mohammad A. Vasef
MD and Kaaren K. Reichard
MD 240 Acute Myeloid Leukemia With t(8;21)/RUNX1::RUNX1T1 Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 244 Acute Myeloid Leukemia With inv(16) or t(16;16)/CBFB::MYH11 Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 248 Acute Promyelocytic Leukemia With t(15;17)/PML::RARA Mohammad A. Vasef
MD 254 Acute Myeloid Leukemia With t(9;11)/MLLT3::KMT2A Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 258 Acute Myeloid Leukemia With t(6:9)/DEK::NUP214 Eric Y. Loo
MD and David R. Czuchlewski
MD 260 Acute Myeloid Leukemia With inv(3) or t(3;3)/GATA2; MECOM Eric Y. Loo
MD and David R. Czuchlewski
MD 262 Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)/RBM15::MRTFA Eric Y. Loo
MD and David R. Czuchlewski
MD 264 Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities Kathryn Foucar
MD and Mohammad A. Vasef
MD 270 Acute Myeloid Leukemia
NOS Kristin Hunt Karner
MD 276 Myeloid Sarcoma Devon Chabot-Richards
MD 280 Myeloid Proliferations Associated With Down Syndrome Eric Y. Loo
MD and David R. Czuchlewski
MD BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM 284 Blastic Plasmacytoid Dendritic Cell Neoplasm Mohammad A. Vasef
MD SECTION 6: MOLECULAR PATHOLOGY OF LYMPHOID NEOPLASMS 292 Overview of Lymphoid Neoplasms Nadine Aguilera
MD 296 Molecular Work-Up of Lymphoid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD DETERMINATION OF CLONALITY IN B-
T-
AND NK-CELL NEOPLASMS 298 Lymphoma-Associated Chromosomal Translocations Kristin Hunt Karner
MD PRECURSOR LYMPHOID NEOPLASMS 302 B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities Kristin Hunt Karner
MD 306 B-Lymphoblastic Leukemia/Lymphoma
BCR::ABL1-Like (Ph-Like ALL) Joanna L. Conant
MD and Mohammad A. Vasef
MD 310 T-Lymphoblastic Leukemia/Lymphoma Mohammad A. Vasef
MD MATURE B-CELL NEOPLASMS 316 Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia Devon Chabot-Richards
MD 322 B-Cell Prolymphocytic Leukemia Aaron Auerbach
MD
MPH 326 Splenic Marginal Zone Lymphoma Aaron Auerbach
MD
MPH and Roberto N. Miranda
MD 332 Hairy Cell Leukemia Mohammad A. Vasef
MD 336 Splenic B-Cell Lymphoma/Leukemia
Unclassifiable Nadine Aguilera
MD 344 Lymphoplasmacytic Lymphoma Aaron Auerbach
MD
MPH 350 Monoclonal Gammopathy of Undetermined Significance Nadine Aguilera
MD 354 Multiple Myeloma (Plasma Cell Myeloma) Nadine Aguilera
MD and Carla S. Wilson
MD
PhD 362 Follicular Lymphoma Aaron Auerbach
MD
MPH
C. Cameron Yin
MD
PhD
and John Schmieg
MD
PhD 370 Mantle Cell Lymphoma Aaron Auerbach
MD
MPH 376 Diffuse Large B-Cell Lymphoma Nadine Aguilera
MD 386 Burkitt Lymphoma Aaron Auerbach
MD
MPH and Carlos Bueso-Ramos
MD
PhD MATURE T- AND NK-CELL NEOPLASMS 394 T-Cell Prolymphocytic Leukemia Nadine Aguilera
MD 398 Chronic Lymphoproliferative Disorder of NK Cells Nadine Aguilera
MD 402 Aggressive NK-Cell Leukemia Nadine Aguilera
MD 406 Extranodal NK-/T-Cell Lymphoma Aaron Auerbach
MD
MPH and L. Jeffrey Medeiros
MD 410 Adult T-Cell Leukemia/Lymphoma Nadine Aguilera
MD 416 Intestinal T-Cell Lymphoma Aaron Auerbach
MD
MPH and Sa A. Wang
MD 424 Hepatosplenic T-Cell Lymphoma Aaron Auerbach
MD
MPH and Roberto N. Miranda
MD 428 Subcutaneous Panniculitis-Like T-Cell Lymphoma Aaron Auerbach
MD
MPH 432 Mycosis Fungoides/Sézary Syndrome Aaron Auerbach
MD
MPH and Sa A. Wang
MD 438 Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders Aaron Auerbach
MD
MPH 442 Peripheral T-Cell Lymphoma
NOS Aaron Auerbach
MD
MPH 448 Nodal Follicular Helper T-Cell Lymphoma Aaron Auerbach
MD
MPH 456 Anaplastic Large Cell Lymphoma
ALK-Negative Mohammad A. Vasef
MD 462 Anaplastic Large Cell Lymphoma
ALK-Positive Mohammad A. Vasef
MD SECTION 7: MOLECULAR PATHOLOGY OF DENDRITIC CELL AND HISTIOCYTIC NEOPLASMS 470 Histiocytic Sarcoma Nadine Aguilera
MD 478 Langerhans Cell Histiocytosis Guanghua Wang
MD 484 Interdigitating Dendritic Cell Sarcoma Aaron Auerbach
MD
MPH and Sa A. Wang
MD 488 Follicular Dendritic Cell Sarcoma Aaron Auerbach
MD
MPH SECTION 8: MOLECULAR PATHOLOGY OF SOLID TUMORS HEAD AND NECK
INCLUDING SINONASAL TUMORS AND SALIVARY GLANDS 494 HPV-Associated Head and Neck Carcinomas Thèrése Bocklage
MD 500 Head and Neck Mucosal Squamous Cell Carcinoma
Non-HPV Related Thèrése Bocklage
MD 506 Important Alterations in Non-HPV-Related Head and Neck Squamous Cell Carcinoma Thèrése Bocklage
MD 508 Translocation-Specific Salivary Gland Tumors Thèrése Bocklage
MD 518 Translocation-Specific Salivary Gland Tumors (Continued) Thèrése Bocklage
MD 526 Nasopharyngeal EBV-Related Squamous Cell Carcinoma Thèrése Bocklage
MD 530 Other Head and Neck Tumors Thèrése Bocklage
MD THYROID 538 Papillary Thyroid Carcinoma Giovanni Insuasti-Beltran
MD 542 Follicular Thyroid Carcinoma Giovanni Insuasti-Beltran
MD 546 Poorly Differentiated Thyroid Carcinoma Von Samedi
MD
PhD 550 Anaplastic Thyroid Carcinoma Von Samedi
MD
PhD 554 Medullary Thyroid Carcinoma Giovanni Insuasti-Beltran
MD LUNG 560 Adenocarcinoma
Lung Jeremy C. Wallentine
MD 568 Squamous Cell Carcinoma
Lung Jeremy C. Wallentine
MD 572 Small Cell Neuroendocrine Carcinoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 576 Mesothelioma Mohammad A. Vasef
MD and Khalil Sheibani
MD
FCAP LUMINAL GASTROINTESTINAL TRACT 580 Gastric Adenocarcinoma M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD 584 Colorectal Adenocarcinoma and Precancerous Lesions M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD 590 Gastrointestinal Stromal Tumor M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD LIVER 598 HNF1A-Inactivated Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 602 ß-Catenin-Activated Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 606 Inflammatory Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 610 Hepatocellular Carcinoma Rama Gullapalli
MD
PhD PANCREATICOBILIARY 614 Pancreatic Ductal Adenocarcinoma Von Samedi
MD
PhD 618 Pancreatic Mucinous Cystic Neoplasm Von Samedi
MD
PhD 620 Pancreatic Intraductal Papillary Mucinous Neoplasm Von Samedi
MD
PhD 622 Cholangiocarcinoma Rama Gullapalli
MD
PhD TESTIS 624 Testicular Germ Cell Tumors Edgar Fischer
MD
PhD KIDNEY 630 Clear Cell Renal Cell Carcinoma Edgar Fischer
MD
PhD 634 Chromophobe Renal Cell Carcinoma Edgar Fischer
MD
PhD 636 Papillary Renal Cell Carcinoma Edgar Fischer
MD
PhD 638 TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas Edgar Fischer
MD
PhD 642 Wilms Tumor Marc Barry
MD 648 Clear Cell Sarcoma of Kidney Marc Barry
MD 650 Oncocytoma Marc Barry
MD 652 Rhabdoid Tumor of Kidney Marc Barry
MD BLADDER 654 Urothelial Carcinoma Marc Barry
MD ADRENAL 660 Pheochromocytoma/Paraganglioma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 666 Adrenal Cortical Carcinoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 672 Neuroblastoma Giovanni Insuasti-Beltran
MD
Thèrése Bocklage
MD
and Samuel Reynolds
MD 680 Adrenal Cortical Adenoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD PROSTATE 684 Prostatic Adenocarcinoma
Acinar Type and High-Grade Prostatic Intraepithelial Neoplasia Edgar Fischer
MD
PhD BREAST 688 ADH and DCIS (Dysplastic
Premalignant) David G. Hicks
MD 694 Ductal Carcinomas David G. Hicks
MD 700 Lobular Carcinoma David G. Hicks
MD 706 Invasive Ductal Carcinoma of No Special Type With Medullary Features Rania Bakkar
MD 710 Metaplastic Breast Carcinoma Rania Bakkar
MD 716 Phyllodes Tumors Rania Bakkar
MD 720 Basal-Like and Triple-Negative Breast Carcinomas David G. Hicks
MD and Susan C. Lester
MD
PhD CERVIX/VULVA/VAGINA 730 Preneoplastic Conditions
Cervix/Vulva/Vagina Nancy Joste
MD 734 Squamous Cell Carcinoma
Cervix/Vulva/Vagina Nancy Joste
MD 738 Adenocarcinoma
Cervix/Vulva/Vagina Nancy Joste
MD UTERUS 742 Endometrial Intraepithelial Neoplasia Lesley Lomo
MD 744 Uterine Endometrioid Carcinoma Lesley Lomo
MD 748 Uterine Serous Carcinoma Lesley Lomo
MD 750 Clear Cell Carcinoma
Uterus Lesley Lomo
MD 754 Uterine Sarcomas Thèrése Bocklage
MD OVARIES/FALLOPIAN TUBE 762 Serous Tumors of Ovary and Fallopian Tube Rania Bakkar
MD 768 Other Surface Epithelial Tumors of Ovary Rania Bakkar
MD 774 Sex Cord-Stromal Tumors of Ovary Rania Bakkar
MD 780 Germ Cell Tumor
Ovary Rania Bakkar
MD and Aaron Auerbach
MD
MPH SKIN 784 Premalignant Conditions
Skin David Cassarino
MD
PhD 788 Melanoma David Cassarino
MD
PhD 792 Squamous Cell Carcinoma
Skin David Cassarino
MD
PhD 796 Basal Cell Carcinoma
Skin David Cassarino
MD
PhD 800 Sebaceous Tumors David Cassarino
MD
PhD 802 Dermatofibroma and Dermatofibrosarcoma Protuberans David Cassarino
MD
PhD BONE 804 Overview of Molecular Pathology of Bone and Soft Tissue Tumors Thèrése Bocklage
MD 810 Osteosarcomas Thèrése Bocklage
MD 818 Ewing Sarcoma Thèrése Bocklage
MD 824 Other Small Round Blue Cell Sarcomas Thèrése Bocklage
MD 832 Giant Cell Tumor of Bone Thèrése Bocklage
MD 838 Intermediate and Malignant Cartilaginous Tumors of Bone Thèrése Bocklage
MD SOFT TISSUE 848 Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors Thèrése Bocklage
MD 858 Liposarcomas Thèrése Bocklage
MD 868 Muscle Sarcomas Thèrése Bocklage
MD 878 Intermediate and Malignant Vascular Tumors Thèrése Bocklage
MD 886 Malignant Peripheral Nerve Sheath Tumor Thèrése Bocklage
MD and David R. Lucas
MD 892 Representative Genetic Findings in Bone and Soft Tissue Tumors Thèrése Bocklage
MD SARCOMAS OF UNCERTAIN DIFFERENTIATION 898 Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations Thèrése Bocklage
MD 908 Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations (Continued) Thèrése Bocklage
MD CNS 916 Glioblastoma
IDH Wildtype Elisabeth Rushing
MD and Mohammad A. Vasef
MD 920 Astrocytoma
IDH-Mutant Elisabeth Rushing
MD and Mohammad A. Vasef
MD 924 Pilocytic Astrocytoma Aaron Auerbach
MD
MPH
Karen SantaCruz
MD
and Elisabeth Rushing
MD 928 Oligodendroglioma
IDH Mutant
and 1p/19q Codeleted Aaron Auerbach
MD
MPH
Karen SantaCruz
MD
and Elisabeth Rushing
MD 932 Ependymal Tumors Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 938 Medulloblastoma Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 944 Choroid Plexus Tumors Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 948 Meningioma Mohammad A. Vasef
MD and Karen SantaCruz
MD 952 Retinoblastoma Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD SECTION 9: QUALITY ASSURANCE AND REGULATORY ISSUES 958 Federal Agencies and Regulation of Laboratories Amer Mahmoud
MD
FCAP 960 FDA Regulations Yongjie Zhou
MD
PhD 966 Proficiency Testing and Accreditation Amer Mahmoud
MD
FCAP
MD 8 DNA Replication
Transcription
and Translation Jeremy C. Wallentine
MD 12 Gene Mutations Jeremy C. Wallentine
MD SECTION 2: COMMON TECHNIQUES FOR ANALYSIS OF ALTERATIONS IN CHROMOSOMES AND DNA 18 Cytogenetics and FISH Mohammad A. Vasef
MD and David R. Czuchlewski
MD 22 Chromosomal Microarray Mohammad A. Vasef
MD and Sibel Kantarci
PhD 26 Amplification Methods Devon Chabot-Richards
MD 30 DNA High-Resolution Melting Curve Analysis Amer Mahmoud
MD
FCAP 32 Sequencing Technologies Eric Y. Loo
MD and Mohammad A. Vasef
MD 36 High-Throughput Methods in Molecular Pathology Rama Gullapalli
MD
PhD 38 DNA Methylation Analysis Devon Chabot-Richards
MD SECTION 3: MOLECULAR GENETIC TESTS IN HEMATOPOIETIC TUMORS 42 BCR::ABL1 Fusion Eric Y. Loo
MD and Mohammad A. Vasef
MD 46 PML::RARA Fusion Devon Chabot-Richards
MD 48 Reverse Transcription PCR for Myeloid Leukemia Transcripts Kristin Hunt Karner
MD 50 FLT3
NPM1
and CEBPA Mutations Devon Chabot-Richards
MD 54 JAK2 Mutations and Rearrangements Mohammad A. Vasef
MD 56 MPL Mutations Eric Y. Loo
MD and David R. Czuchlewski
MD 58 Calreticulin (CALR) Mutations Eric Y. Loo
MD and Mohammad A. Vasef
MD 60 CSF3R Mutations Amer Mahmoud
MD
FCAP 62 SETBP1 Mutations Amer Mahmoud
MD
FCAP 64 KIT Mutations Eric Y. Loo
MD and Mohammad A. Vasef
MD 68 IDH1 and IDH2 Mutations Eric Y. Loo
MD and David R. Czuchlewski
MD 70 Other Mutations and Gene Panel Testing in Myeloid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD 72 Immunoglobulin Heavy (IGH) Chain Gene Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 76 T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 80 T-Cell Receptor Beta (TRB) Chain Gene Rearrangements Mohammad A. Vasef
MD and Anna P. Matynia
MD 84 Southern Blot Analysis of Antigen Receptor Genes Mohammad A. Vasef
MD 86 EBV-Associated Human Neoplasms Mohammad A. Vasef
MD 94 MYD88 Mutation Giovanni Insuasti-Beltran
MD 96 NOTCH1 Mutation Giovanni Insuasti-Beltran
MD 98 EZH2 Mutation Amer Mahmoud
MD
FCAP SECTION 4: MOLECULAR GENETIC TESTS IN SOLID TUMORS
BONE AND SOFT TISSUE TUMORS
AND CNS TUMORS 104 ALK Rearrangements and Mutations Guanghua Wang
MD 106 ROS1 Rearrangements Mohammad A. Vasef
MD and David R. Czuchlewski
MD 108 RET Rearrangements Eric Y. Loo
MD and David R. Czuchlewski
MD 110 FISH for MET Amplifications Devon Chabot-Richards
MD 114 FISH for ERBB2 (HER2) Amplifications M. Carmen Frias Kletecka
MD and Kristin Hunt Karner
MD 116 KRAS Mutations Guanghua Wang
MD 118 BRAF Mutations Yongjie Zhou
MD
PhD and Guanghua Wang
MD 120 EGFR Mutations Guanghua Wang
MD 122 Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next-Generation Sequencing) Mohammad A. Vasef
MD and David R. Czuchlewski
MD 124 Targeted Hotspot Gene Panel Table Mohammad A. Vasef
MD and David R. Czuchlewski
MD 130 MGMT Promoter Gene Methylation Assay Devon Chabot-Richards
MD SECTION 5: MOLECULAR PATHOLOGY OF MYELOID NEOPLASMS 134 Molecular Work-Up of Myeloid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD MYELOPROLIFERATIVE NEOPLASMS 136 Chronic Myeloid Leukemia
BCR::ABL1-Positive Mohammad A. Vasef
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 144 Chronic Neutrophilic Leukemia Devon Chabot-Richards
MD and David R. Czuchlewski
MD 148 Polycythemia Vera Mohammad A. Vasef
MD and M. Carmen Frias Kletecka
MD 152 Primary Myelofibrosis Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD 156 Essential Thrombocythemia Giovanni Insuasti-Beltran
MD 160 Chronic Eosinophilic Leukemia
NOS Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD 162 Myeloproliferative Neoplasm
Unclassifiable Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and Daniel Babu
MD MASTOCYTOSIS 166 Mastocytosis Mohammad A. Vasef
MD MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND GENE REARRANGEMENT 174 Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions Devon Chabot-Richards
MD and David R. Czuchlewski
MD PREMALIGNANT CLONAL HEMATOPOIESIS AND CYTOPENIAS 178 VEXAS Syndrome Mohammad A. Vasef
MD and Michael M. Franklin
DO 182 Clonal Hematopoiesis and Premalignant Clonal Cytopenia Mohammad A. Vasef
MD MYELODYSPLASTIC SYNDROME (MDS) 184 Overview and Classification of Myelodysplastic Syndrome Devon Chabot-Richards
MD
David R. Czuchlewski
MD
and Carla S. Wilson
MD
PhD 188 Myelodysplastic Syndrome With Mutated SF3B1 Mohammad A. Vasef
MD and Carla S. Wilson
MD
PhD 192 Myelodysplastic Syndrome
NOS Kristin Hunt Karner
MD 200 Myelodysplastic Syndrome With del(5q) Giovanni Insuasti-Beltran
MD 204 Myelodysplastic Syndrome With TP53 Multihit Mutations Kristin Hunt Karner
MD 206 Myelodysplastic Syndrome/Acute Myeloid Leukemia Kristin Hunt Karner
MD 208 Pediatric Myelodysplastic Syndrome and Refractory Cytopenia of Childhood Devon Chabot-Richards
MD and Carla S. Wilson
MD
PhD MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS 214 Overview of Myelodysplastic/Myeloproliferative Neoplasms Devon Chabot-Richards
MD 216 Chronic Myelomonocytic Leukemia Kristin Hunt Karner
MD 220 Atypical Chronic Myeloid Leukemia Devon Chabot-Richards
MD 224 Juvenile Myelomonocytic Leukemia Devon Chabot-Richards
MD and Qian-Yun Zhang
MD
PhD 228 Myelodysplastic/Myeloproliferative Neoplasm
NOS Devon Chabot-Richards
MD and Kathryn Foucar
MD ACUTE MYELOID LEUKEMIA 232 Overview of Acute Myeloid Leukemia Mohammad A. Vasef
MD and Kaaren K. Reichard
MD 240 Acute Myeloid Leukemia With t(8;21)/RUNX1::RUNX1T1 Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 244 Acute Myeloid Leukemia With inv(16) or t(16;16)/CBFB::MYH11 Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 248 Acute Promyelocytic Leukemia With t(15;17)/PML::RARA Mohammad A. Vasef
MD 254 Acute Myeloid Leukemia With t(9;11)/MLLT3::KMT2A Devon Chabot-Richards
MD
Kaaren K. Reichard
MD
and David R. Czuchlewski
MD 258 Acute Myeloid Leukemia With t(6:9)/DEK::NUP214 Eric Y. Loo
MD and David R. Czuchlewski
MD 260 Acute Myeloid Leukemia With inv(3) or t(3;3)/GATA2; MECOM Eric Y. Loo
MD and David R. Czuchlewski
MD 262 Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)/RBM15::MRTFA Eric Y. Loo
MD and David R. Czuchlewski
MD 264 Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities Kathryn Foucar
MD and Mohammad A. Vasef
MD 270 Acute Myeloid Leukemia
NOS Kristin Hunt Karner
MD 276 Myeloid Sarcoma Devon Chabot-Richards
MD 280 Myeloid Proliferations Associated With Down Syndrome Eric Y. Loo
MD and David R. Czuchlewski
MD BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM 284 Blastic Plasmacytoid Dendritic Cell Neoplasm Mohammad A. Vasef
MD SECTION 6: MOLECULAR PATHOLOGY OF LYMPHOID NEOPLASMS 292 Overview of Lymphoid Neoplasms Nadine Aguilera
MD 296 Molecular Work-Up of Lymphoid Neoplasms Mohammad A. Vasef
MD and David R. Czuchlewski
MD DETERMINATION OF CLONALITY IN B-
T-
AND NK-CELL NEOPLASMS 298 Lymphoma-Associated Chromosomal Translocations Kristin Hunt Karner
MD PRECURSOR LYMPHOID NEOPLASMS 302 B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities Kristin Hunt Karner
MD 306 B-Lymphoblastic Leukemia/Lymphoma
BCR::ABL1-Like (Ph-Like ALL) Joanna L. Conant
MD and Mohammad A. Vasef
MD 310 T-Lymphoblastic Leukemia/Lymphoma Mohammad A. Vasef
MD MATURE B-CELL NEOPLASMS 316 Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia Devon Chabot-Richards
MD 322 B-Cell Prolymphocytic Leukemia Aaron Auerbach
MD
MPH 326 Splenic Marginal Zone Lymphoma Aaron Auerbach
MD
MPH and Roberto N. Miranda
MD 332 Hairy Cell Leukemia Mohammad A. Vasef
MD 336 Splenic B-Cell Lymphoma/Leukemia
Unclassifiable Nadine Aguilera
MD 344 Lymphoplasmacytic Lymphoma Aaron Auerbach
MD
MPH 350 Monoclonal Gammopathy of Undetermined Significance Nadine Aguilera
MD 354 Multiple Myeloma (Plasma Cell Myeloma) Nadine Aguilera
MD and Carla S. Wilson
MD
PhD 362 Follicular Lymphoma Aaron Auerbach
MD
MPH
C. Cameron Yin
MD
PhD
and John Schmieg
MD
PhD 370 Mantle Cell Lymphoma Aaron Auerbach
MD
MPH 376 Diffuse Large B-Cell Lymphoma Nadine Aguilera
MD 386 Burkitt Lymphoma Aaron Auerbach
MD
MPH and Carlos Bueso-Ramos
MD
PhD MATURE T- AND NK-CELL NEOPLASMS 394 T-Cell Prolymphocytic Leukemia Nadine Aguilera
MD 398 Chronic Lymphoproliferative Disorder of NK Cells Nadine Aguilera
MD 402 Aggressive NK-Cell Leukemia Nadine Aguilera
MD 406 Extranodal NK-/T-Cell Lymphoma Aaron Auerbach
MD
MPH and L. Jeffrey Medeiros
MD 410 Adult T-Cell Leukemia/Lymphoma Nadine Aguilera
MD 416 Intestinal T-Cell Lymphoma Aaron Auerbach
MD
MPH and Sa A. Wang
MD 424 Hepatosplenic T-Cell Lymphoma Aaron Auerbach
MD
MPH and Roberto N. Miranda
MD 428 Subcutaneous Panniculitis-Like T-Cell Lymphoma Aaron Auerbach
MD
MPH 432 Mycosis Fungoides/Sézary Syndrome Aaron Auerbach
MD
MPH and Sa A. Wang
MD 438 Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders Aaron Auerbach
MD
MPH 442 Peripheral T-Cell Lymphoma
NOS Aaron Auerbach
MD
MPH 448 Nodal Follicular Helper T-Cell Lymphoma Aaron Auerbach
MD
MPH 456 Anaplastic Large Cell Lymphoma
ALK-Negative Mohammad A. Vasef
MD 462 Anaplastic Large Cell Lymphoma
ALK-Positive Mohammad A. Vasef
MD SECTION 7: MOLECULAR PATHOLOGY OF DENDRITIC CELL AND HISTIOCYTIC NEOPLASMS 470 Histiocytic Sarcoma Nadine Aguilera
MD 478 Langerhans Cell Histiocytosis Guanghua Wang
MD 484 Interdigitating Dendritic Cell Sarcoma Aaron Auerbach
MD
MPH and Sa A. Wang
MD 488 Follicular Dendritic Cell Sarcoma Aaron Auerbach
MD
MPH SECTION 8: MOLECULAR PATHOLOGY OF SOLID TUMORS HEAD AND NECK
INCLUDING SINONASAL TUMORS AND SALIVARY GLANDS 494 HPV-Associated Head and Neck Carcinomas Thèrése Bocklage
MD 500 Head and Neck Mucosal Squamous Cell Carcinoma
Non-HPV Related Thèrése Bocklage
MD 506 Important Alterations in Non-HPV-Related Head and Neck Squamous Cell Carcinoma Thèrése Bocklage
MD 508 Translocation-Specific Salivary Gland Tumors Thèrése Bocklage
MD 518 Translocation-Specific Salivary Gland Tumors (Continued) Thèrése Bocklage
MD 526 Nasopharyngeal EBV-Related Squamous Cell Carcinoma Thèrése Bocklage
MD 530 Other Head and Neck Tumors Thèrése Bocklage
MD THYROID 538 Papillary Thyroid Carcinoma Giovanni Insuasti-Beltran
MD 542 Follicular Thyroid Carcinoma Giovanni Insuasti-Beltran
MD 546 Poorly Differentiated Thyroid Carcinoma Von Samedi
MD
PhD 550 Anaplastic Thyroid Carcinoma Von Samedi
MD
PhD 554 Medullary Thyroid Carcinoma Giovanni Insuasti-Beltran
MD LUNG 560 Adenocarcinoma
Lung Jeremy C. Wallentine
MD 568 Squamous Cell Carcinoma
Lung Jeremy C. Wallentine
MD 572 Small Cell Neuroendocrine Carcinoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 576 Mesothelioma Mohammad A. Vasef
MD and Khalil Sheibani
MD
FCAP LUMINAL GASTROINTESTINAL TRACT 580 Gastric Adenocarcinoma M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD 584 Colorectal Adenocarcinoma and Precancerous Lesions M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD 590 Gastrointestinal Stromal Tumor M. Carmen Frias Kletecka
MD and Joshua Anspach Hanson
MD LIVER 598 HNF1A-Inactivated Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 602 ß-Catenin-Activated Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 606 Inflammatory Hepatocellular Adenoma Giovanni Insuasti-Beltran
MD and Joshua Anspach Hanson
MD 610 Hepatocellular Carcinoma Rama Gullapalli
MD
PhD PANCREATICOBILIARY 614 Pancreatic Ductal Adenocarcinoma Von Samedi
MD
PhD 618 Pancreatic Mucinous Cystic Neoplasm Von Samedi
MD
PhD 620 Pancreatic Intraductal Papillary Mucinous Neoplasm Von Samedi
MD
PhD 622 Cholangiocarcinoma Rama Gullapalli
MD
PhD TESTIS 624 Testicular Germ Cell Tumors Edgar Fischer
MD
PhD KIDNEY 630 Clear Cell Renal Cell Carcinoma Edgar Fischer
MD
PhD 634 Chromophobe Renal Cell Carcinoma Edgar Fischer
MD
PhD 636 Papillary Renal Cell Carcinoma Edgar Fischer
MD
PhD 638 TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas Edgar Fischer
MD
PhD 642 Wilms Tumor Marc Barry
MD 648 Clear Cell Sarcoma of Kidney Marc Barry
MD 650 Oncocytoma Marc Barry
MD 652 Rhabdoid Tumor of Kidney Marc Barry
MD BLADDER 654 Urothelial Carcinoma Marc Barry
MD ADRENAL 660 Pheochromocytoma/Paraganglioma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 666 Adrenal Cortical Carcinoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD 672 Neuroblastoma Giovanni Insuasti-Beltran
MD
Thèrése Bocklage
MD
and Samuel Reynolds
MD 680 Adrenal Cortical Adenoma M. Carmen Frias Kletecka
MD and Samuel Reynolds
MD PROSTATE 684 Prostatic Adenocarcinoma
Acinar Type and High-Grade Prostatic Intraepithelial Neoplasia Edgar Fischer
MD
PhD BREAST 688 ADH and DCIS (Dysplastic
Premalignant) David G. Hicks
MD 694 Ductal Carcinomas David G. Hicks
MD 700 Lobular Carcinoma David G. Hicks
MD 706 Invasive Ductal Carcinoma of No Special Type With Medullary Features Rania Bakkar
MD 710 Metaplastic Breast Carcinoma Rania Bakkar
MD 716 Phyllodes Tumors Rania Bakkar
MD 720 Basal-Like and Triple-Negative Breast Carcinomas David G. Hicks
MD and Susan C. Lester
MD
PhD CERVIX/VULVA/VAGINA 730 Preneoplastic Conditions
Cervix/Vulva/Vagina Nancy Joste
MD 734 Squamous Cell Carcinoma
Cervix/Vulva/Vagina Nancy Joste
MD 738 Adenocarcinoma
Cervix/Vulva/Vagina Nancy Joste
MD UTERUS 742 Endometrial Intraepithelial Neoplasia Lesley Lomo
MD 744 Uterine Endometrioid Carcinoma Lesley Lomo
MD 748 Uterine Serous Carcinoma Lesley Lomo
MD 750 Clear Cell Carcinoma
Uterus Lesley Lomo
MD 754 Uterine Sarcomas Thèrése Bocklage
MD OVARIES/FALLOPIAN TUBE 762 Serous Tumors of Ovary and Fallopian Tube Rania Bakkar
MD 768 Other Surface Epithelial Tumors of Ovary Rania Bakkar
MD 774 Sex Cord-Stromal Tumors of Ovary Rania Bakkar
MD 780 Germ Cell Tumor
Ovary Rania Bakkar
MD and Aaron Auerbach
MD
MPH SKIN 784 Premalignant Conditions
Skin David Cassarino
MD
PhD 788 Melanoma David Cassarino
MD
PhD 792 Squamous Cell Carcinoma
Skin David Cassarino
MD
PhD 796 Basal Cell Carcinoma
Skin David Cassarino
MD
PhD 800 Sebaceous Tumors David Cassarino
MD
PhD 802 Dermatofibroma and Dermatofibrosarcoma Protuberans David Cassarino
MD
PhD BONE 804 Overview of Molecular Pathology of Bone and Soft Tissue Tumors Thèrése Bocklage
MD 810 Osteosarcomas Thèrése Bocklage
MD 818 Ewing Sarcoma Thèrése Bocklage
MD 824 Other Small Round Blue Cell Sarcomas Thèrése Bocklage
MD 832 Giant Cell Tumor of Bone Thèrése Bocklage
MD 838 Intermediate and Malignant Cartilaginous Tumors of Bone Thèrése Bocklage
MD SOFT TISSUE 848 Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors Thèrése Bocklage
MD 858 Liposarcomas Thèrése Bocklage
MD 868 Muscle Sarcomas Thèrése Bocklage
MD 878 Intermediate and Malignant Vascular Tumors Thèrése Bocklage
MD 886 Malignant Peripheral Nerve Sheath Tumor Thèrése Bocklage
MD and David R. Lucas
MD 892 Representative Genetic Findings in Bone and Soft Tissue Tumors Thèrése Bocklage
MD SARCOMAS OF UNCERTAIN DIFFERENTIATION 898 Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations Thèrése Bocklage
MD 908 Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations (Continued) Thèrése Bocklage
MD CNS 916 Glioblastoma
IDH Wildtype Elisabeth Rushing
MD and Mohammad A. Vasef
MD 920 Astrocytoma
IDH-Mutant Elisabeth Rushing
MD and Mohammad A. Vasef
MD 924 Pilocytic Astrocytoma Aaron Auerbach
MD
MPH
Karen SantaCruz
MD
and Elisabeth Rushing
MD 928 Oligodendroglioma
IDH Mutant
and 1p/19q Codeleted Aaron Auerbach
MD
MPH
Karen SantaCruz
MD
and Elisabeth Rushing
MD 932 Ependymal Tumors Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 938 Medulloblastoma Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 944 Choroid Plexus Tumors Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD 948 Meningioma Mohammad A. Vasef
MD and Karen SantaCruz
MD 952 Retinoblastoma Mohammad A. Vasef
MD and Fausto J. Rodríguez
MD SECTION 9: QUALITY ASSURANCE AND REGULATORY ISSUES 958 Federal Agencies and Regulation of Laboratories Amer Mahmoud
MD
FCAP 960 FDA Regulations Yongjie Zhou
MD
PhD 966 Proficiency Testing and Accreditation Amer Mahmoud
MD
FCAP