Diclofenac Potassium Tablet for Colon Targeting: Formulation - Shinde, Anilkumar;Jarag, Ravindra;More, Harinath
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The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Ethyl Cellulose(N22), Cross Povidone and Sodium Starch Glycolate as a superdisintegrants and Instacoat EN super II as a enteric coat to the colone specific tablet. A 33 randomized full factorial design, 3 level and 3 factors were used. The concentration of Hydroxy propyl cellulose (X1), concentration of HPMC K4M (X2) and concentration of Ethyl cellulose (X3) were selected as independent variables. The percentage drug release at…mehr

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Produktbeschreibung
The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Ethyl Cellulose(N22), Cross Povidone and Sodium Starch Glycolate as a superdisintegrants and Instacoat EN super II as a enteric coat to the colone specific tablet. A 33 randomized full factorial design, 3 level and 3 factors were used. The concentration of Hydroxy propyl cellulose (X1), concentration of HPMC K4M (X2) and concentration of Ethyl cellulose (X3) were selected as independent variables. The percentage drug release at 12 hours (Q12), percentage friability and hardness of tablet were selected as dependent variables for optimization study. The core, press coat tablets were compressed by rotatory tablet machine evaluated with different parameters like diameter, thickness, average weight, hardness, friability, kinetic release data. Hardness of tablets was found to be in the range of 7-8 kg/cm2. The enteric coated tablets containing diclofenac potassium released 38.12 % at the end of 12 hrs by in vitro release study.
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Autorenporträt
Dr. Anilkumar J. Shinde, M.Pharm Ph.D (Farmácia) da Universidade Shivaji, Kolhapur. Tem 26 anos de experiência em marketing, ensino e investigação. Atualmente, trabalha como Professor Associado no Departamento de Farmácia da Faculdade de Farmácia Bharati Vidyapeeth, Kolhapur. Tem 64 trabalhos de investigação, 5 artigos de revisão e 2 patentes publicadas.