Social and cultural pluralism of our contemporary reality has pointed out all the different facets of students' population in terms of readiness, interests, experiences, culture, needs and learning abilities, bringing thus the traditional, one-dimensional way of teaching and learning, down to inadequacy. On the basis of such rationale, it seems that Differentiated Instruction and Learning comprises a modern teaching perspective which is capable of corresponding to the complexity of the multi-leveled activation of each pupil's psycho-mental potentiality, to the acquisition of skills, to their actual involvement into the educational process and the development of motivation which leads to building new knowledge.