The present investigation focuses on the change in some physiological parameters concerning the liver and kidney functions induced after experimental oral infection of the albino mouse, Mus musculus, with the metacercariae of prohemistomum vivax. These were obtained from the skeletal muscles of the Nile fishes Oreochromis niloticus, Clarias gariepinus and Bagrus bajad. Also, Native SDS-Proteins lactate dehydrogenase (LDH), Glucose-6-phosphate dehydrogenase(G6PDH) , 6-phosphogluconate dehydrogenase (6PGDH) , acid phosphatase (ACP) and alkaline phosphatase (ALP) in liver and kidney tissues of mice Mus musculus were electrophoretically analyzed before and after 4 weeks post infection with the digenetic trematode Prohemistomum vivax . In conclusion, it seems possible to postulate that on the long run, the human being health is correlated with the infection by this parasite, which has expressed many hazards upon the ingestion of larval digenetic stages in the musculature of several fish caught from local water. So it must be eating non-polluted fishes which caughted from clean water or farms.