This book suggests a methodology to apply Digital Twin to manufacturing facilities for keeping the model updated and simulated in real time. Real-Time Location Sensing (RTLS) technology with transmitter tags, receiver nodes, and gateways (IOT) deployed at the facility. Manage transformation matrix for each asset in Digital manufacturing facility at PLM/CAD software. Discrete Event Simulation tools integrated into PLM to run model directly from PLM in real-time. Tags attached to each physical asset send the signal to the receiver when asset movement or orientation occurs at the physical facility, Tags attached to each asset send the signal to the receiver. The receiver sends pre-processed information to the gateway, which acts as an edge device to process and convert those signals as transformation matric, which is synchronized to the PLM system. Now digital manufacturing facility is up-to-date. Any facility change requirement can be done in this digital model and simulated in real-time for the quickest decision.