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The global warming related archaeal endosymbiosis leads to generation of RNA viroids and DNA viroids of the human system. The RNA viroids can hybridise with gut bacteria and human genomic elements generating RNA viruses like SARS and COVID 19. The homo neanderthalis are resistant the RNA and DNA viruses generated by the endosymbiotic archaea as the archaea synthesize the antiviral compound digoxin. The homo sapiens do not have endosymbiotic archaeal growth and also do not synthesize digoxin and they become extinct due to the COVID 19 infection. The homo neanderthalis are the superspreaders and generators of COVID 19 which infects homo sapiens and kills them. The homo sapiens are susceptible because of lack of endosymbiotic archaea and digoxin. Digoxin can be administered to homo sapien patients of COVID 19 and they can be cured. Digoxin is the perfect, ultimate and prime anti-COVID 19 drug. Archaeal digoxin plays a part of human species evolution.