Direct N-Trifluoromethylation - Niedermann, Katrin
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Chapter 2 of this thesis presents an X-ray structure correlation and reactivity study of hypervalent iodine compounds designed to facilitate the search for more effective reagents for the electrophilic trifluoromethylation of hard nucleophiles. In the second part of this thesis (Chapter 3) two methods for the N-trifluoromethylation of organonitrogen compounds utilizing hypervalent iodine compounds are described. Firstly, in a Ritter-type reaction, N-(trifluoromethyl)imine derivatives were prepared via acid-catalyzed trifluoromethylation of nitriles in the presence of various azoles. Secondly,…mehr

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Produktbeschreibung
Chapter 2 of this thesis presents an X-ray structure correlation and reactivity study of hypervalent iodine compounds designed to facilitate the search for more effective reagents for the electrophilic trifluoromethylation of hard nucleophiles. In the second part of this thesis (Chapter 3) two methods for the N-trifluoromethylation of organonitrogen compounds utilizing hypervalent iodine compounds are described. Firstly, in a Ritter-type reaction, N-(trifluoromethyl)imine derivatives were prepared via acid-catalyzed trifluoromethylation of nitriles in the presence of various azoles. Secondly, the efficient and mild direct N-trifluoromethylation of various electron-rich heterocycles such as pyrazoles, indazoles, triazoles, tetrazoles and to a certain extent benzimidazole is described. Both methods provide ready access to a wide variety of stable N-trifluoromethylated compounds; rare substances which are otherwise very difficult to obtain.
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Autorenporträt
Dr. sc. ETH Zürich: Studied Chemistry at ETH Zurich from 2003 to 2007 (BSc 2006, MSc 2007). After an eight month industrial internship at F. Hoffmann-La Roche Ltd, Basel, she returned to ETH Zurich where she graduated under the supervision of Prof. A. Togni in the department of inorganic chemistry.