Directly Compressible Co-processed Excipient for Sustained Release - Patel, Hetal;Ghayal, Aakash;Mishra, Ashish
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There is a strong need for new excipient in the market to modulate flow property, compressibility, solubility, disintegration, stability, dissolution or bioavailability of drug molecule. Developing a new adjuvant is uneconomical and laborious from the standpoint of safety and regulatory clearances. Hence, the formulation scientists are constantly working on modification of existing excipients to meet the ever-changing demands of industry. Co-processed excipients are combinations of two or more excipients that possess performance advantages that cannot be achieved using a physical admixture of…mehr

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Produktbeschreibung
There is a strong need for new excipient in the market to modulate flow property, compressibility, solubility, disintegration, stability, dissolution or bioavailability of drug molecule. Developing a new adjuvant is uneconomical and laborious from the standpoint of safety and regulatory clearances. Hence, the formulation scientists are constantly working on modification of existing excipients to meet the ever-changing demands of industry. Co-processed excipients are combinations of two or more excipients that possess performance advantages that cannot be achieved using a physical admixture of the same combination of excipients. Present research work deals with development of multifunctional excipient, co-processed glyceryl monostearate- dicalcium phosphate dihydrate, to improve flowability and compressibility of the blend and to provide sustained release of highly water soluble drug, tramadol hydrochloride. There are a wide variety of drugs in whose formulation the prepared co-processed excipient of glycerylmonostearate and dicalcium phosphate dihydrate can be used. Hence, its commercial viability needs to be exploited in all case.
Autorenporträt
Ms. Hetal Patel, awarded B.Pharm degree from Nirma University, Ahmedabad, India and M.Pharm in Pharmaceutics from NMIMS University, Mumbai, India. Pursuing PhD degree from Uka Tarsadia University, Bardoli, India. Working as an Assistant Professor at Maliba Pharmacy College, Bardoli, India.