In Ethiopia tsetse, transmitted trypanosomosis is one of the major important parasitic diseases in most parts of the country and causes a huge economic loss annually. This may have contributed to the country left undeveloped. Despite the continued interventions were applied on tsetse and trypanosomosis control at the study area still significant numbers of tsetse flies were caught and higher trypanosomosis prevalence were recorded. Regarding prevention and control of the parasite and the vector, all implemented control programs should be coordinated based on river basin wise unless scattered control program may continuously fail.