Diverse Effects of Hypoxia on Tumor Progression

Herausgegeben:Simon, M. Celeste

• Gebundenes Buch

Produktbeschreibung

Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

Produktdetails

• Current Topics in Microbiology and Immunology 345
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 12658459, 978-3-642-13328-2
• 2010
• Seitenzahl: 156
• Erscheinungstermin: 5. September 2010
• Englisch
• Abmessung: 241mm x 160mm x 15mm
• Gewicht: 378g
• ISBN-13: 9783642133282
• ISBN-10: 3642133282
• Artikelnr.: 29925744

Inhaltsangabe

The HIF-2?-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization.- Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance.- Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression.- The Role of Hypoxia Regulated microRNAs in Cancer.- Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration.- Hypoxia-Inducible Factors as Essential Regulators of Inflammation.- Hypoxia and Metastasis in Breast Cancer.