DNA Binding and Micellar Loading of Anti-cancer Uracil Derivatives - Zafar, Fateen
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In the present work, characterization using electrochemical technique in conjunction with electronic spectroscopy and computational studies was done to suggest a redox mechanism and to develop a structure activity relationship. DNA binding studies showed high values of binding constant that is suggestive of uracils being more effective anticancer drugs in comparison to the clinically used drugs. In the last part of the work i.e. Drug Surfactant interaction, the strategy adopted for high drug loading of these anti cancerous drugs and sustained release capabilities of the carrier will help…mehr

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Produktbeschreibung
In the present work, characterization using electrochemical technique in conjunction with electronic spectroscopy and computational studies was done to suggest a redox mechanism and to develop a structure activity relationship. DNA binding studies showed high values of binding constant that is suggestive of uracils being more effective anticancer drugs in comparison to the clinically used drugs. In the last part of the work i.e. Drug Surfactant interaction, the strategy adopted for high drug loading of these anti cancerous drugs and sustained release capabilities of the carrier will help improve the uptake of these drugs by the tumor cells leading to a considerable improvement in the cancer treatment at the preclinical stage.
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Autorenporträt
The Author is a very dedicated professional in the field of Physical Chemistry, graduated from Quaid-i-University, Islamabad. She is teaching at Government Degree College for Women, Rawalpindi & earned her majors in colloid and interfacial phenomena. Her recent research is also published in science direct which was highly appreciated in the circle.