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DNA-binding proteins are proteins that are composed of DNA- binding domains and thus have a specific or general affinity for either single or double stranded DNA. Sequence- specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair. However there are some known narrow-groove DNA-binding ligands such as Netropsin, Distamycin, Hoechst 33258, Pentamidine and others . DNA- binding proteins include transcription factors which modulate the process of transcription, various polymerases, nucleases which cleave…mehr

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DNA-binding proteins are proteins that are composed of DNA- binding domains and thus have a specific or general affinity for either single or double stranded DNA. Sequence- specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair. However there are some known narrow-groove DNA-binding ligands such as Netropsin, Distamycin, Hoechst 33258, Pentamidine and others . DNA- binding proteins include transcription factors which modulate the process of transcription, various polymerases, nucleases which cleave DNA molecules, and histones which are involved in chromosome packaging in the cell nucleus. DNA-binding proteins can incorporate such domains as the zinc finger, the helix-turn-helix, and the leucine zipper (among many others) that facilitate binding to nucleic acid.