DNA Damage, DNA Repair and Disease

Volume 1
Herausgeber: Dizdaroglu, Miral; Lloyd, R Stephen

• Gebundenes Buch

Produktbeschreibung

The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

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Produktdetails

• Verlag: RSC Publishing
• Seitenzahl: 428
• Erscheinungstermin: 18. November 2020
• Englisch
• Abmessung: 236mm x 160mm x 28mm
• Gewicht: 816g
• ISBN-13: 9781788018890
• ISBN-10: 1788018893
• Artikelnr.: 59296313

Inhaltsangabe

Biomonitoring of DNA Damage in Humans; Tandem and Clustered Lesions from
Radicals in Nucleic Acids from a Single Initial Chemical Event; Oxidative
DNA Damage and Repair in G-Quadruplexes; Oxidatively Induced DNA Damage:
Mechanisms and Measurement; Oxidation of the C5' Position in DNA and the
Role of Purine 5',8-Cyclo-2'-deoxynucleoside Lesions; Ferroptosis and
Oxidative DNA Damage; DNA-Protein Cross-Links: Formation, Genotoxicity and
Repair; Substrate Specificities of DNA Glycosylases in vitro and in vivo;
Special Problems for Base Excision Repair in Coping with
Oxidatively-induced DNA Damage; Genomic Uracil in Biology, Immunity and
Cancer; Alternative DNA Repair Pathways to Handle Complex DNA Damage
Generated by Oxidative Stress and Anticancer Drugs; Redox Stress Responses
and Human Disease: NTHL1 at the Intersection of DNA Damage Repair and
Cancer; Emerging Roles of Non-Canonical RNA Binding Proteins in Repair of
Genome Damage Linked to Human Pathologies; Modulation of DNA Glycosylase
Activities via Small Molecules; DNA Repair in the Development of Human
Diseases and Therapy;