DNA Methylation: Development, Genetic Disease and Cancer

Herausgegeben:Doerfler, Walter; Böhm, Petra

• Broschiertes Buch

Produktbeschreibung

It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.

Produktdetails

• Current Topics in Microbiology and Immunology 310
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-642-06830-0
• Softcover reprint of hardcover 1st ed. 2006
• Seitenzahl: 296
• Erscheinungstermin: 16. November 2010
• Englisch
• Abmessung: 235mm x 155mm x 17mm
• Gewicht: 453g
• ISBN-13: 9783642068300
• ISBN-10: 3642068308
• Artikelnr.: 32070127

Inhaltsangabe

The Regulation of Chromatin and DNA-Methylation Patterns in Blood Cell Development.- Methylation Dynamics in the Early Mammalian Embryo: Implications of Genome Reprogramming Defects for Development.- Epigenetic Regulation in Drosophila.- Epimutations in Human Disease.- Epigenotypes of Latent Herpesvirus Genomes.- Epigenetics of Complex Diseases: From General Theory to Laboratory Experiments.- MSL Proteins and the Regulation of Gene Expression.- DNA Methylation Profiles of Female Steroid Hormone-Driven Human Malignancies.- Genome-wide Analysis of DNA Methylation Changes in Human Malignancies.- Decreased Fidelity in Replicating DNA Methylation Patterns in Cancer Cells Leads to Dense Methylation of a CpG Island.- Methylation of Endogenous Human Retroelements in Health and Disease.- Cancer-Linked DNA Hypomethylation and Its Relationship to Hypermethylation.