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This Special Issue welcomed original research papers, but was not limited to cooperative works between academia and pharmaceutical companies where reformulations or original dosage form designs were performed. Papers or reviews including the principles of Quality by Design to improve the bioavailability of drugs belonging to BCS Classes of II or IV were warmly encouraged for submission. We were looking for manuscripts that optimized innovative technology through the design of experiments as well. Non-pharma institutes or departments and their innovative research projects were also invited to contribute to this Special Issue if their novel and original results could be adapted to dosage form formulation or production.