High Quality Content by WIKIPEDIA articles! Downtown San José is the central business district of San José, California, United States. The area is generally located north of Interstate 280 and east of Guadalupe Parkway, which roughly parallels Guadalupe River. The region is bound to the north by U.S. Route 101 and to the east by Coyote Creek (Santa Clara County). The ZIP code for the business district of downtown San José is 95113, and the residential area is covered by ZIP codes 95110, 95112 and 95113.