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Epilepsy is a chronic disorder and treatment is often life long. Poor or non compliance with medication is a wide spread problem and is considered the major cause of unsuccessful drug treatment in epilepsy. In this book will explore the factors associated with non compliance among epilepsy patients attending Neurology Clinic, HUSM from January 2008 until November 2008. The percentage of drug non compliant was 52.2% and the factors that contribute to non compliant were duration of epilepsy, patients' understanding about their illness and medication barrier. Medication barrier that were significantly related with drug compliance includes the complexity of the drug regime and cost and physical of the medication. This book should give useful information to professionals who involve in health management and care of chronic diseases.