Mukund S. Chorghade (Hrsg.)

Drug Discovery and Development, 2 Volume Set

Herausgegeben:Chorghade, Mukund S.

• Gebundenes Buch

Produktbeschreibung

This innovative two-volume set offers a unique, integrated presentation of the full spectrum of operations involved in drug discovery and development. The set covers the strategies, tactics, milestones, and benchmarks throughout the entire sequence of operations, from discovering a drug to prescribing it. This approach helps readers understand and appreciate how all the elements of basic research, clinical trials, manufacturing, and business development are combined and coordinated to bring new drugs to market.

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This two-volume set provides a full account of the entire sequence of drug development, from conceptualizing the drug, creating a library of candidates, and conducting clinical trials, to optimizing the synthetic route, marketing the drug, and developing delivery methods. Comprehensive in scope, the set bridges the gap between medicinal and process chemistry.
Discussion includes the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer. Case studies examine the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil). Full chapters are devoted to combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics. Industrial chemists, biologists, biochemists, and business people in the pharmaceutical industry will all benefit from this authoritative reference.

The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary.

The second volume describes optimizing the synthetic route; manufacturing, outsourcing, and marketing the drug, including coloring; and developing delivery methods.

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Produktdetails

• Verlag: Wiley & Sons
• Artikelnr. des Verlages: 14639846000
• 1. Auflage
• Seitenzahl: 904
• Erscheinungstermin: 1. Januar 2008
• Englisch
• Abmessung: 263mm x 185mm x 51mm
• Gewicht: 1800g
• ISBN-13: 9780471398462
• ISBN-10: 0471398462
• Artikelnr.: 11442650

Autorenporträt

Mukund S. Chorghade, PHD, is President of Chorghade Enterprises, Inc., a firm based in Natick, Massachusetts that provides consultations to major pharmaceutical companieson collaborations with worldwide academic, government, and industrial laboratories; European technology-based companies; process reengineering; and project management of technology transfer.

Inhaltsangabe

Bioactive Molecules in Medicinal Plants: A Perspective on their Therapeutic
Action / S C Taneja, G N Qazi
Natural Products as an Inspiration for the Discovery of New High-Throughput
Chemical Synthesis Tools / Steven V Ley, Ian R Baxendale, Deborah A
Longbottom, Rebecca M Myers
Insulin Sensitizers: Emerging Therapeutics / Braj B Lohray, Vidya B Lohray
Criteria for Industrial Readiness of Chiral Catalysis Technology for the
Synthesis of Pharmaceuticals / Raymond McCague, Ian C Lennon
Enantioselective Synthesis of Propargyl Alcohols as Multifunctional
Synthons / J S Yadav, S Chandrasekhar
Carbohydrates: From Chirons to Mimics / G V M Sharma, Palakodety Radha
Krishna
Meeting the Challenges of Process Development and Scale-up of Active
Pharmaceutical Ingredients / Yatendra Kumar, B Vijayaraghavan
Importance of Polymorphs and Salts in the Pharmaceutical Industry / Bipin
Pandey, Vidya B Lohray, Braj B Lohray
Role of Outsourcing in Drug Manufacture / Peter Pollak
Regulation-Driven Process Chemistry / Shrikant V Kulkarni
Chemical Process Scale-Up Tools: Mixing Calculations, Statistical Design of
Experiments, and Automated Laboratory Reactors / Andrei A Zlota
Library Quality Metrics / Richard L Wife, Johan Tijhuis
Tying a GABA from Copenhagen to Chicago: The Chemistry of Tiagabine /
Mukund S Chorghade, Mahendra N Deshpande, Richard J Pariza Building
Contract Research Businesses Based on Integration of
Basic and Applied Research / Mukund S Chorghade, Mukund K Gurjar, C V
Ramana, Sreenivas Punna
Principles and Practice of Clinical Drug Development / Colin Scott
Index.
Volume 1. Drug discovery [chapters 1-16]
Volume 2. Drug development [chapters 17-31].
From patent to prescription : paving the perilous path to profit / Richard
J. Pariza
Medicinal chemistry in the new millennium : a glance into the future / Paul
W. Erhardt
Contemporary drug discovery / Lester A. Mitscher, Apurba Dutta
Combinatorial chemistry in the drug discovery process / Ian Hughes
Parallel solution-phase synthesis / Norton P. Peet, Hwa-Ok Kim
Timing of analog research in medicinal chemistry / Jänos Fischer, Aniko¿
Gere
Possible alternatives to high-throughput screening / Camille G. Wermuth
Proteomics and drug discovery / Susan Dana Jones, Peter G. Warren
Using drug metabolism databases during drug design and development / Paul
W. Erhardt
Discovery of the antiulcer drug Tagamet / C. Robin Ganellin
Discovery of potent nonpeptide vasopressin receptor antagonists / Bruce E.
Maryanoff
Discovery and development of the ultrashort-acting analgesic Remifentanil /
Paul L. Feldman
Discovery and development of Nevirapine / Karl Grozinger, John Proudfoot,
Karl Hargrave
Applications of nuclear imaging in drug discovery and development / John W.
Babich, William C. Eckelman
Polymeric sequestrants as nonabsorbed human therapeutics / Pradeep K. Dhal,
Chad C. Huval, S. Randall Holmes-Farley
Botanical immunomodulators and chemoprotectants in cancer therapy / Bhushan
Patwardhan, Manish Gautam, Sham Diwanay
Bioactive molecules in medicinal plants : a perspective on their
therapeutic action / S.C. Taneja, G.N. Qazi
Natural products as an inspiration for the discovery of new high-throughput
chemical synthesis tools / Steven V. Ley, Ian R. Baxendale, Deborah A.
Longbottom, Rebecca M. Myers
Insulin sensitizers : emerging therapeutics / Braj B. Lohray, Vidya B.
Lohray
Criteria for industrial readiness of chiral catalysis technology for the
synthesis of pharmaceuticals / Raymond McCague, Ian C. Lennon
Enantioselective synthesis of propargyl alcohols as multifunctional
synthons / J.S. Yadav, S. Chandrasekhar Carbohydrates : from chirons to
mimics / G.V.M. Sharma, Palakodety Radha Krishna
Meeting the challenges of process development and scale-up of active
pharmaceutical ingredients / Yatendra Kumar, B. Vijayaraghavan
Importance of polymorphs and salts in the pharmaceutical industry / Bipin
Pandey, Vidya B. Lohray, Braj B. Lohray
Role of outsourcing in drug manufacture / Peter Pollak
Regulation-driven process chemistry / Shrikant V. Kulkarni
Chemical process scale-up tools : mixing calculations, statistical design
of experiments, and automated laboratory reactors / Andrei A. Zlota
Library quality metrics / Richard L. Wife, Johan Tijhuis
Tying a GABA from Copenhagen to Chicago : the chemistry of Tiagabine /
Mukund S. Chorghade, Mahendra N. Deshpande, Richard J. Pariza
Building contract research businesses based on integration of basic and
applied research / Mukund S. Chorghade, Mukund K. Gurjar, C.V. Ramana,
Sreenivas Punna
Principles and practice of clinical drug development / Colin Scott

Rezensionen

"There is much worthwhile information here ... Particularly the longest contribution by Paul Ehrhardt on the future of medicinal chemistry." ( Chemistry World , September 2008)
"This book is reasonably priced, well written, and produced." ( Journal of Medicinal Chemistry , 2008)