Mukund S. Chorghade (ed.)

Drug Discovery and Development, Volume 1

Drug Discovery
Herausgegeben von Chorghade, Mukund S.

• Gebundenes Buch

Produktbeschreibung

This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners.

Includes case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil)
Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson s disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer
Contains chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics
The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary.

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Produktdetails

• Drug Discovery and Development Vol.1
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 476
• Erscheinungstermin: 1. Juli 2006
• Englisch
• Abmessung: 257mm x 184mm x 27mm
• Gewicht: 952g
• ISBN-13: 9780471398486
• ISBN-10: 0471398489
• Artikelnr.: 21849332

Autorenporträt

Mukund S. Chorghade, PHD, is President of Chorghade Enterprises, Inc., a firm based in Natick, Massachusetts that provides consultations to major pharmaceutical companieson collaborations with worldwide academic, government, and industrial laboratories; European technology-based companies; process reengineering; and project management of technology transfer.

Inhaltsangabe

Contributors.
Preface.
1. From Patent to Prescription: Paving the Perilous Path to Profit (Richard
J. Pariza).
2. Medicinal Chemistry in the New Millennium: A Glance into the Future
(Paul W. Erhardt).
ADMET-Related Synergies, 59
3. Contemporary Drug Discovery (Lester A. Mitscher and Apurba Dutta).
4. Combinatorial Chemistry in the Drug Discovery Process (Ian Hughes).
5. Parallel Solution-Phase Synthesis (Norton P. Peet and Hwa-Ok Kim).
6. Timing of Analog Research in Medicinal Chemistry (János Fischer and
Anikó Gere).
7. Possible Alternatives to High-Throughput Screening (Camille G. Wermuth).
8. Proteomics and Drug Discovery (Susan Dana Jones and Peter G. Warren).
Appendix: Public-Domain Software Tools and Databases.
9. Using Drug Metabolism Databases During Drug Design and Development (Paul
W. Erhardt).
10. Discovery of the Antiulcer Drug Tagamet (C. Robin Ganellin).
11. Discovery of Potent Nonpeptide Vasopressin Receptor Antagonists (Bruce
E. Maryanoff).
12. Discovery and Development of the Ultrashort-Acting Analgesic
Remifentanil (Paul L. Feldman).
13. Discovery and Development of Nevirapine (Karl Grozinger, John
Proudfoot, and Karl Hargrave).
14. Applications of Nuclear Imaging in Drug Discovery and Development (John
W. Babich and William C. Eckelman).
15. Polymeric Sequestrants as Nonabsorbed Human Therapeutics (Pradeep K.
Dhal, Chad C. Huval, and S. Randall Holmes-Farley).
16. Botanical Immunomodulators and Chemoprotectants in Cancer Therapy
(Bhushan Patwardhan, Sham Diwanay, and Manish Gautam).
Index.