Drug Discovery for Leishmaniasis

Herausgeber: Rivas, Luis; Gil, Carmen

• Gebundenes Buch

Produktbeschreibung

Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania.

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Produktdetails

• Drug Discovery
• Verlag: Royal Society of Chemistry
• Seitenzahl: 422
• Erscheinungstermin: 1. November 2017
• Englisch
• Abmessung: 234mm x 163mm x 28mm
• Gewicht: 788g
• ISBN-13: 9781782628897
• ISBN-10: 1782628894
• Artikelnr.: 48813788

Inhaltsangabe

Leishmaniasis, Impact and Therapeutic Needs; Anti-leishmanial Drug
Discovery: Past, Present and Future Perspectives; From Bench to Bedside:
Development and Optimization of Clinical Therapies for Visceral
Leishmaniasis; Drug Assay Methodology in Leishmaniasis: From the Microplate
to Image Analysis; The Pursuit of Novel Anti-leishmanial Agents by
High-throughput Screening (HTS) of Chemical Libraries; Omics and Their
Impact on the Development of Chemotherapy Against Leishmania; In silico
Tools for Target Identification and Drug Molecular Docking in Leishmania;
Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs;
Natural Products as a Source of New Drugs Against Leishmania;
Organometallic Compounds in Chemotherapy Against Leishmania; New Avenues
for Drug Delivery in Leishmania: Using Treatment of Visceral Leishmaniasis
with Amphotericin B as an Exemplar; Addressing the Molecular Biology of
Leishmania for Drug Development; The Physical Matrix of the Plasma Membrane
as a Target: The Charm of Drugs with Low Specificity; Nutrient Transport
and Sensing as Pharmacological Targets for Leishmaniasis; Carbon Metabolism
as a Drug Target in Leishmania; The Redox Metabolism and Oxidative Stress
in Leishmania as a Crossroads for the Lethal Effect of Drugs; DNA
Topoisomerases as Promising Targets for Leishmania Chemotherapy; Molecular
Basis of Drug Resistance in Leishmania; The Macrophage-Parasite Interface
as a Chemotherapeutic Target in Leishmaniasis