Drug Discovery for Schizophrenia

Herausgeber: Lipina, Tatiana; Roder, John

• Gebundenes Buch

Produktbeschreibung

Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia will cover new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book will outline a change in the way schizophrenia is treated by moving away from focusing only on treating symptoms in patients. Innovative drugs will emerge from deeper comprehension of the pathological processes that emerge earlier in life, hence, providing strategies for preventative therapy to alter the course of this mental disorder. Amongst other current topics, the book will cover new findings in genetics and epigenetics, progress in animal models for schizophrenia and the usage of opto- and chemogenetic tools for drug discovery in schizophrenia. The combination of these important areas will benefit psychiatric neuroscience, filling the gaps in the knowledge of neurobiology of schizophrenia and providing novel perspectives for future drug development.

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Produktdetails

• Verlag: RSC Publishing
• Seitenzahl: 289
• Erscheinungstermin: 13. Mai 2015
• Englisch
• Abmessung: 236mm x 160mm x 23mm
• Gewicht: 590g
• ISBN-13: 9781782620266
• ISBN-10: 1782620265
• Artikelnr.: 42035587

Inhaltsangabe

Genetics of schizophrenia: Genome-Wide Association Study
Epigenetics of schizophrenia
Cognitive dysfunction in schizophrenia
Modelling schizophrenia
Glutamate hypothesis of schizophrenia
Dopamine hypothesis of schizophrenia
Neurodevelopmental hypothesis of schizophrenia
Genetic factors and hippocampal dysfunction in schizophrenia
Exome study of schizophrenia
Protein-protein interactions as a potentially new drug target in schizophrenia
Optogenetic approach to dissect neurobiology of schizophrenia
MicroRNAs in neuronal function and dysfunction
Application of pluripotent stem cells in schizophrenia
Deep brain stimulation of the hippocampus and prefrontal cortex as alternative approach in treatment of schizophrenia
Neuroimmunology of brain development in schizophrenia and immunotherapy