ACCESSIBLE, COMPREHENSIVE INFORMATION ON DRUG-DNA INTERACTIONS. This informative guide is a thorough source of information on the structural basis of drug-DNA interactions and their underlying empirical evidence. It helps readers understand the underlying mechanisms of the interactions, thus expediting research and aiding in the more efficient design of new and more effective drugs with lesser side effects. With a wealth of information gleaned from diverse studies and combined in a logical, practical format, Drug-DNA Interactions: Structures and Spectra: * Describes what types of structural…mehr
ACCESSIBLE, COMPREHENSIVE INFORMATION ON DRUG-DNA INTERACTIONS. This informative guide is a thorough source of information on the structural basis of drug-DNA interactions and their underlying empirical evidence. It helps readers understand the underlying mechanisms of the interactions, thus expediting research and aiding in the more efficient design of new and more effective drugs with lesser side effects. With a wealth of information gleaned from diverse studies and combined in a logical, practical format, Drug-DNA Interactions: Structures and Spectra: * Describes what types of structural information can be obtained using particular techniques * Classified structural and spectroscopic studies of drug-DNA adducts first by bonding types and then by the structure type of the drug * Covers intercalating drugs, groove-binding drugs, covalent-bonding drugs, strand-breaking drugs, and metal-containing drugs * Focuses on structural and bonding information obtained by using physico-chemical methods (such as X-ray crystallography, NMR spectroscopy, and molecular modeling), and optical spectroscopy (such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), and infrared (IR) and Raman spectroscopy) This is a hands-on reference for professionals in pharmaceutical industries and academia, pharmacologists, organic chemists, biochemists, and bioanalytical chemists. It also helps students in chemistry, biochemistry, and pharmacology understand the complex drug-DNA interactions that could pave the way for tomorrow's breakthrough therapies.
Kazuo Nakamoto pioneered the use of metal isotopes to elucidate the involvement of metals in low-frequency vibrations in metallic complexes and was among the first to use matrix isolation techniques to prepare and characterize unstable specie. He is the author of Infrared and Raman Spectra of Inorganic and Coordination compounds, Fifth Edition (Wiley). Masamichi Tsuboi studies DNA and RNA structures, drug-DNA interaction, protein conformation, protein-nucleic acid recognition, and virus structure using a variety of physicochemical and biomedical techniques including X-ray diffraction, UV-Visible, IR/Raman, and NMR spectroscopy. Gary D. Strahan uses physico-chemical techniques to understand biological systems relevant to pharmaceutical discovery and agricultural and natural product analyses. His work has emphasized spectroscopic methods, NMR, and computational modeling to determine the structures and properties of multistranded DNA, drug-DNA complexes, carbohydrates, and other biomolecules, as well as metabonomic and chemometric studies.
Inhaltsangabe
Preface.
Introduction.
1. DNA Structures and Spectra.
1.1. DNA Structures.
1.2. Electronic Spectra.
1.3. Vibrational Spectra.
1.4. NMR Spectra.
1.5. Electron Spin Resonance Spectra.
1.6. X-Ray Crystallography.
1.7. Molecular Modeling an molecular Mechanics.
2. Intercalating Drugs.
2.1. Acridine Dyes.
2.2. Ethidium Bromide.
2.3. Aclacinomycin.
2.4. Sequence Preference.
2.5. Bis- and Tris- Intercalators.
3. Groove- Binding Drugs.
3.1. Netropsin and Distamycin.
3.2. Derivatives of Netropsin and Distamycin.
3.3. Hoechst 33258, SN6999, and their Derivatives.
3.4. Chromomycin, Mithramycin, and Other GC Binders.
3.5. Groove Binding and Intercalation.
4. Covalent Bonding Drugs.
4.1. (+) CC1065 and Related Drugs.
4.2. Anthramycin and Tomaymycin.
4.3. Ecteinascidins.
4.4. Mitomycins.
4.5. Intercalating Alkylators.
5. Strand-Breaking Drugs.
5.1. Bleomycins.
5.2. Enediyne Antibiotics.
6. Metal-Containing Drugs.
6.1. Cisplatin.
6.2. Cisplatin Derivatives.
6.3. Transplatin and Derivatives.
6.4. Monofunctional Platinum Complexes.
6.5. Polynuclear and High-valent Platinum Complexes.
