Drug-Drug Interactions
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Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes in drug metabolism and drug interactionsthe integral role of pharmacogenetics in metabolism-based drug-drug interactionsin vivo - in vitro correlations (reversible, mechanism-based inhibition, induction)in silico approaches enabling structure-activi...
Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.
Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:
key interplay between transporters and enzymes in drug metabolism and drug interactionsthe integral role of pharmacogenetics in metabolism-based drug-drug interactionsin vivo - in vitro correlations (reversible, mechanism-based inhibition, induction)in silico approaches enabling structure-activity and structure-function studieshigh-throughput screening and GLP methods for evaluating drug interactions in vitrothe use of transgenic animal models to evaluate drug interactions
Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.
Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:
key interplay between transporters and enzymes in drug metabolism and drug interactionsthe integral role of pharmacogenetics in metabolism-based drug-drug interactionsin vivo - in vitro correlations (reversible, mechanism-based inhibition, induction)in silico approaches enabling structure-activity and structure-function studieshigh-throughput screening and GLP methods for evaluating drug interactions in vitrothe use of transgenic animal models to evaluate drug interactions
Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.
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