Drug Efficacy, Safety, and Biologics Discovery
Emerging Technologies and Tools
Herausgegeben von Ekins, Sean; Xu, Jinghai J.
Drug Efficacy, Safety, and Biologics Discovery
Emerging Technologies and Tools
Herausgegeben von Ekins, Sean; Xu, Jinghai J.
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Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.…mehr
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- Produktdetails
- Wiley Series on Technologies for the Pharmaceutical Industry
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 416
- Erscheinungstermin: 14. Januar 2009
- Englisch
- Abmessung: 236mm x 163mm x 26mm
- Gewicht: 701g
- ISBN-13: 9780470225554
- ISBN-10: 0470225556
- Artikelnr.: 25427354
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
- Wiley Series on Technologies for the Pharmaceutical Industry
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 416
- Erscheinungstermin: 14. Januar 2009
- Englisch
- Abmessung: 236mm x 163mm x 26mm
- Gewicht: 701g
- ISBN-13: 9780470225554
- ISBN-10: 0470225556
- Artikelnr.: 25427354
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
Acknowledgments.
Contributors.
PART I: DRUG EFFICACY AND SAFETY TECHNOLOGY.
1. Focus on Fundamentals: Towards Better Therapeutic Index Prediction
(Jinghai J. Xu and Li J. Yu).
2. High-Throughput Protein-Based Technologies and Computational Models for
Drug Development, Efficacy and Toxicity (Leonidas G. Alexopoulos, Julio
Saez-Rodriguez and Christopher W. Espelin).
3. Cellular Systems Biology Applied to Pre-Clinical Safety Testing: A Case
Study of CellCiphrTM Profiling (Lawrence Vernetti, William Irwin, Kenneth
A. Giuliano, Albert Gough, Kate Johnston and D. Lansing Taylor).
4. Systems Pharmacology, Biomarkers and Biomolecular Networks (Aram
Adourian, Thomas N. Plasterer, Raji Balasubramanian, Ezra Jennings,
Shunguang Wang, Jan van der Greef, Robert McBurney, Pieter Muntendam, and
Noubar Afeyan).
5. Zebrafish Models for Human Diseases and Drug Discovery (Hanbing Zhong,
Ning-Ai Liu and Shuo Lin).
6. Toxicity Pathways and Models: Mining for Potential Side Effects (Sean
Ekins and Josef Scheiber).
7. Computational Systems Biology Modeling of Dosimetry and Cellular
Response Pathways (Qiang Zhang, Yu-Mei Tan, Sudin Bhattacharya and Melvin
E. Andersen).
8. Stem Cell Technology for Embryotoxicity, Cardiotoxicity and
Hepatotoxicity Evaluation (Julio C. Davila, Donald B. Stedman, Sandra J.
Engle, Howard I. Pryor II and Joseph P. Vacanti).
9. Telemetry Technology for Preclinical Drug Discovery and Development (Yi
Yang).
PART II. BIOLOGICS TECHNOLOGY.
10. Nanotechnology to Improve Oral Drug Delivery (Mayank D. Bhavsar,
Shardool Jain, and Mansoor M. Amiji).
11. Functional Glycomics and the Future of Glycomic Drugs (Ram
Sasisekharan).
12. Modeling Efficacy and Safety of Engineered Biologics (Jeff Chabot and
Bruce Gomes).
13. Regulation of Gene Expression by Small, Non-Coding RNAs: Practical
Applications (Roman Herrara and Eric Tien).
PART III. FUTURE PERSPECTIVE.
14. Future Perspectives of Biological Engineering in Pharmaceutical
Research: The Paradigm of Modeling, Mining, Manipulation and Measurements
(Jinghai J. Xu, Sean Ekins, Michael McGlashen and Douglas Lauffenburger).
Index.
Acknowledgments.
Contributors.
PART I: DRUG EFFICACY AND SAFETY TECHNOLOGY.
1. Focus on Fundamentals: Towards Better Therapeutic Index Prediction
(Jinghai J. Xu and Li J. Yu).
2. High-Throughput Protein-Based Technologies and Computational Models for
Drug Development, Efficacy and Toxicity (Leonidas G. Alexopoulos, Julio
Saez-Rodriguez and Christopher W. Espelin).
3. Cellular Systems Biology Applied to Pre-Clinical Safety Testing: A Case
Study of CellCiphrTM Profiling (Lawrence Vernetti, William Irwin, Kenneth
A. Giuliano, Albert Gough, Kate Johnston and D. Lansing Taylor).
4. Systems Pharmacology, Biomarkers and Biomolecular Networks (Aram
Adourian, Thomas N. Plasterer, Raji Balasubramanian, Ezra Jennings,
Shunguang Wang, Jan van der Greef, Robert McBurney, Pieter Muntendam, and
Noubar Afeyan).
5. Zebrafish Models for Human Diseases and Drug Discovery (Hanbing Zhong,
Ning-Ai Liu and Shuo Lin).
6. Toxicity Pathways and Models: Mining for Potential Side Effects (Sean
Ekins and Josef Scheiber).
7. Computational Systems Biology Modeling of Dosimetry and Cellular
Response Pathways (Qiang Zhang, Yu-Mei Tan, Sudin Bhattacharya and Melvin
E. Andersen).
8. Stem Cell Technology for Embryotoxicity, Cardiotoxicity and
Hepatotoxicity Evaluation (Julio C. Davila, Donald B. Stedman, Sandra J.
Engle, Howard I. Pryor II and Joseph P. Vacanti).
9. Telemetry Technology for Preclinical Drug Discovery and Development (Yi
Yang).
PART II. BIOLOGICS TECHNOLOGY.
10. Nanotechnology to Improve Oral Drug Delivery (Mayank D. Bhavsar,
Shardool Jain, and Mansoor M. Amiji).
11. Functional Glycomics and the Future of Glycomic Drugs (Ram
Sasisekharan).
12. Modeling Efficacy and Safety of Engineered Biologics (Jeff Chabot and
Bruce Gomes).
13. Regulation of Gene Expression by Small, Non-Coding RNAs: Practical
Applications (Roman Herrara and Eric Tien).
PART III. FUTURE PERSPECTIVE.
14. Future Perspectives of Biological Engineering in Pharmaceutical
Research: The Paradigm of Modeling, Mining, Manipulation and Measurements
(Jinghai J. Xu, Sean Ekins, Michael McGlashen and Douglas Lauffenburger).
Index.