Drug-excipient-shell interactions using thermoplastic capsules - Misic, Zdravka;Kuentz, Martin;Imanidis, Georgios
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This book introduced novel starch-based thermoplastic capsules (S-PVA-Cs) and demonstrated their advantage over SGCs with respect to hydrophilic lipid-based formulations. Release studies in biorelevant media revealed differences in how formulations hydrated and interacted with the shell material. Drug-excipient-shell interactions were observed in various capsule types (SGCs, S-PVA-Cs, and VegaGels®) at different levels of biopharmaceutical in vitro testing. A better mechanistic understanding was attained that may guide future development of soft capsule products.

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Produktbeschreibung
This book introduced novel starch-based thermoplastic capsules (S-PVA-Cs) and demonstrated their advantage over SGCs with respect to hydrophilic lipid-based formulations. Release studies in biorelevant media revealed differences in how formulations hydrated and interacted with the shell material. Drug-excipient-shell interactions were observed in various capsule types (SGCs, S-PVA-Cs, and VegaGels®) at different levels of biopharmaceutical in vitro testing. A better mechanistic understanding was attained that may guide future development of soft capsule products.
Autorenporträt
Zdravka Misic, di nazionalità croata, ha conseguito un dottorato di ricerca in Scienze Farmaceutiche presso l'Università di Basilea, in Svizzera. Ha iniziato la sua carriera come scienziato della formulazione in Teva nel 2004. Nel 2009 si è trasferita in Svizzera all'ETH Zürich come borsista ESKAS. Dal 2014 lavora con successo a nuovi sistemi di somministrazione di vitamine presso DSM, in Svizzera.