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A biopharmaceutical, also known as a biological medical product, biological or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semi-synthesized from biological sources. Different from totally synthesized pharmaceuticals, they include vaccines, blood, blood components, allergenics, somatic cells, gene therapies, tissues, recombinant therapeutic protein, and living cells used in cell therapy. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinations of these substances, or may be living cells or tissues. They (or their precursors or components) are isolated from living sources human, animal, plant, fungal or microbial.Vaccines, many vaccines are grown in tissue cultures.Gene therapy, viral gene therapy involves artificially manipulating a virus to include a desirable piece of genetic material. Pharmacokinetics (PK), the study of the disposition of a drugThe disposition of a drug includes the processes of ADME. Pharmacodynamics, drug actions at receptor sites and the physiological/chemical effects produced by these actions. Studies of drug mechanisms of action at the molecular level.