Drug Reactions and Metabolomic Profiles in HIV Patients on Treatment - Ndakala, Frank
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"Studying antiretroviral drugs related long-term adverse drug reactions and underlying metabolomic profiles in HIV-infected patients from both resource-poor and resource-rich medical settings has potential to contribute immensely to the new innovative field of personalized medicine. For example, this work reports how commonly reported adverse drug reactions including polyneuropathy and lipodystrophy accounted for most of the drug changes in Kenyan sex workers. Further, it was demonstrated that many plasma metabolites undergo significant alterations in HIV-infected patients before and after…mehr

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Produktbeschreibung
"Studying antiretroviral drugs related long-term adverse drug reactions and underlying metabolomic profiles in HIV-infected patients from both resource-poor and resource-rich medical settings has potential to contribute immensely to the new innovative field of personalized medicine. For example, this work reports how commonly reported adverse drug reactions including polyneuropathy and lipodystrophy accounted for most of the drug changes in Kenyan sex workers. Further, it was demonstrated that many plasma metabolites undergo significant alterations in HIV-infected patients before and after long-term exposure to ART. The current results may serve as a starting point for the search of new biomolecules that could be potential biomarkers for early detection of adverse drug reactions."
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Autorenporträt
Dr. Frank Ndakala is an Assistant Director of Research at the Directorate of Research, Science, and Technology. He holds a Ph.D. in Tropical and Infectious Diseases from the University of Nairobi. He is a fellow of the International Infectious Diseases and Global Health Training Programme (IID&GHTP) and Serono Symposia International Foundation.