Herbert M. Pinedo (Amsterdam Vrije Universiteit), Giuseppe Giaccone (Amsterdam Vrije Universiteit)

Drug Resistance in the Treatment of Cancer

• Broschiertes Buch

Produktbeschreibung

Reviews the mechanisms and clinical implications of drug resistance in cancer, considered to be the most significant obstacle to the cure of cancer today. Topics covered include multiple drug resistance and its reversal, topoisomerase drugs, apoptosis, dose intensity and escalation, gene therapy and haematopoietic support.

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Produktdetails

• Cancer: Clinical Science in Practice
• Verlag: Cambridge University Press
• Seitenzahl: 340
• Erscheinungstermin: 29. November 2006
• Englisch
• Abmessung: 229mm x 152mm x 20mm
• Gewicht: 507g
• ISBN-13: 9780521030748
• ISBN-10: 0521030749
• Artikelnr.: 21759750

Inhaltsangabe

List of contributors
Series editor's preface
Abbreviations
1. Resistance mechanisms to antimetabolites Erdem Göker, Richard Gorlick and Joseph R. Bertino
2. Resistance to antitumor alkylating agents and cisplatin Beverly A. Teicher and Emil Frei III
3. The MDR genes Lyn Mickley and Antonio Tito Fojo
4. Topoisomerase genes and resistance to topoisomerase inhibitors Giuseppe Giaccone
5. Genes that modulate apoptosis: major determinants of drug resistance John A. Hickman
6. Clinical implications of drug resistance Henk M. W. Verheul and Herbert M. Pinedo
7. The reversal of multidrug resistance William S. Dalton
8. Effect of dose and schedule on chemotherapeutic drug resistance David Fennelly, George Raptis, John P. A. Crown and Larry Norton
9. Circumvention of drug resistance by high-dose chemotherapy in solid tumors Elisabeth G. E. de Vries, Wil Dolsma, Geke A. P. Hospers and Nanno H. Mulder
10. Enhancing drug effectiveness by gene transfer Karol Sikora
Index.