Drug Stereochemistry

Analytical Methods and Pharmacology, Third Edition
Herausgeber: Jozwiak, Krzysztof; Wainer, Irving W.; Lough, W. J.

• Gebundenes Buch

Produktbeschreibung

This third edition has been updated to cover all aspects of chiral drugs from the academic, governmental, industrial, and clinical perspectives. New topics include the use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery, how stereochemistry impacts decisions made in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) stages of drug discovery, and issues faced during the final stages of the drug development process. It also discusses the impact of International Conference on Harmonisation (ICH) on the use of single isomer drugs, chiral switches, molecular chiral recognition, and legal perspectives.

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Produktdetails

• Verlag: CRC Press
• 3. Auflage
• Seitenzahl: 332
• Erscheinungstermin: 23. April 2012
• Englisch
• Abmessung: 235mm x 157mm x 22mm
• Gewicht: 633g
• ISBN-13: 9781420092387
• ISBN-10: 1420092383
• Artikelnr.: 26556781

Autorenporträt

Professor Krzysztof Jó¿wiak is head of laboratory of medicinal chemistry and neuroengineering of Medical University of Lublin, Poland Dr W John Lough is reader in pharmaceutical analysis in the Department of Pharmacy, Health and Well-Being at the University of Sunderland, UK Irving W. Wainer, Ph.D. is senior investigator, in the Bioanalytical Chemistry and Drug Discovery Section, Laboratory for Clinical Investigation, National Institute of Aging/National Institutes of Health

Inhaltsangabe

Introduction: The Early History of Stereochemistry: From the Discovery of
Molecular Asymmetry and the First Resolution of a Racemate by Pasteur to
the Asymmetrical Chiral Carbon of Van't Hoff and Le Bel. Stereochemical
Terms and Concepts: An Overview. Molecular Chiral Recognition: An
Introduction and Overview. The Role of Stereo-Chemistry in the Development
of ACE Inhibitors: Nature to Clinic. The Separation, Preparation and
Identification of Stereochemically Pure Drugs: Indirect Methods for the
Chromatographic Resolution of Drug Enantiomers: Synthesis and Separation of
Diastereo-Metric Derivatives. The Direct Resolution of Enantiometric Drugs
by Chiral Phase Gas Chromatography. HPLC Chiral Stationary Phases for the
Stereochemical Resolution of Enantiometric Compounds: The Current State of
the Art. Enantioselective Separations by Capillary Electrophoresis. Recent
Advances in the Synthesis of Enantiomerically Pure Compounds. Production
Scale Preparation of Enantiomerically Pure Compounds by Chromatography and
Synthetic Approaches. Spectrometric Identification and Characterization of
Chiral Molecules. Pharmacokinetic and Pharmacodynamic Differences Between
Drug Stereoisomers: Stereochemical Considerations in the ADMET Stage of
Drug Development. Stereoselective Biotransformations: Toxico-Logical
Consequences and Implications. Stereoselective Interactions with Enzymes
and Their Use in Drug Development. Stereoselective Transport of Drugs
Across Epithelia. Clinical Pharmacokinetics and pharmacodynamics of
Stereoisomeric Drugs. Industrial and Regulatory Perspectives on Single
Isomer Drugs: Regulatory Perspective of the Development of New
Stereoisomeric Drugs. Stereochemically Pure Drugs Versus Racemates: An
Overview. The Development and Marketing of Single Isomer Drugs vs
Racemates: A Legal Perspective.