This book comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics.
This book comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics.
Dr Glynis Nicholls has over 18 years experience within the pharmaceutical field in both academia and industry (including 7 years at GlaxoSmithKline and 5 years at AstraZeneca), specializing in drug transporter science from discovery through to clinical development. Dr Nicholls has played a leading role in writing and implementing internal transporter strategies within the industry, as well as collaborating across multiple international locations with internal and external colleagues on transporter-related projects and scientific developments, including PhD projects. Dr Kuresh Youdim has 9 years academic experience in the field of nutrition and neuroscience, plus 10 years pharmaceutical experience across multiple disciplines within drug discovery and development (including 8 years at Pfizer and 2 years at Roche) predominantly in the field of drug-drug interactions and PBPK modelling.
Inhaltsangabe
Overview of drug transporter families and their role in drug development Liver transporters and their involvement in the hepatocellular uptake and export systems of organic anions Intestinal transporters Kidney transporters CNS transporters Lung transporters The use of in vitro and in silico systems for investigating transporter interactions The use of transgenic and knockout in vivo systems for investigating transporter interactions Modelling and simulation of transporter interactions Clinical Drug-Drug Interactions: An industrial Pharmaceutical Perspective Regulatory requirements, Labelling and Drug Transporters Recent Advances and Emerging Technologies Bioinformatics Regulation of transporters Transporter Pharmacogenomics Transporter Imaging Transporters and Proteomics
Overview of drug transporter families and their role in drug development Liver transporters and their involvement in the hepatocellular uptake and export systems of organic anions Intestinal transporters Kidney transporters CNS transporters Lung transporters The use of in vitro and in silico systems for investigating transporter interactions The use of transgenic and knockout in vivo systems for investigating transporter interactions Modelling and simulation of transporter interactions Clinical Drug-Drug Interactions: An industrial Pharmaceutical Perspective Regulatory requirements, Labelling and Drug Transporters Recent Advances and Emerging Technologies Bioinformatics Regulation of transporters Transporter Pharmacogenomics Transporter Imaging Transporters and Proteomics
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