The drug control is vital to all phases of dentistry and a thorough knowledge of the art and science of it is very essential for proper patient care. The route and rate of drug administration, dosage, onset and duration of action and even the possibility of toxicity are all influenced by the unique physiology of child. There is always a necessity to adjust dosages of medications to accomodate to their lower weight and body size. Hence dental practitioners should have a thorough knowledge regarding the commonly prescribed drugs in pediatric dentistry.