Dupuytren¿s Disease

Pathobiochemistry and Clinical Management
Mitarbeit:Delbrück, Axel; Brenner, Peter; Berger, Alfred

• Broschiertes Buch

Produktbeschreibung

In this volume a distinguished group of internationallyrenowned clinicians and basic researchers discuss thepresent state of knowledge of the etiologyand pathogenesisof Dupuytren's contracture, a disease responsible for aconsiderable portion of disabilities within the workingpopulation allover the world. Although the riddle of howthe contracture of the palmar fascia develops is stillunsolved, the data on the pathobiochemistry and clinic ofDupuytren's Disease achieved in recent years has led to abetter understanding of the biochemical and morphologicalprocesses underlying the deformation and malfunction of theafflicted tissues. Research in Dupuytren's Disease nowenters the era of molecular medicine, which opens up newexperimental means of studying the pathological changeswhich occur during the formation of the contracture on amolecular level. In particular, data are presented as to therole of specific biological macromoleculesinfluencing thephenotype expression of the palmar fascia cells which areinvolved in autoimmune reactions and present both at thecell surface as well as in the extracellular matrix toregulate cell-to-cell and cell-to-matrix interactions. Invitro cell culture models to investigate fibro-cyticmodulations are available and havebeen applied to study theeffects of specific biological molecules on isolated cellsfrom healthy palmar fascia and Dupuytren's contracture.Complementary evaluations of morphological, epidemiological,and clinical data contribute essentially to the presentunderstanding of the etiology and pathogenesis ofDupuytren's Disease. This comprehensive and informativesummary of the state of the art is completed by numerousreferences affixed to the individual contributions.

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Produktdetails

• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-540-57239-8
• 1994.
• Seitenzahl: 320
• Erscheinungstermin: 18. März 1994
• Englisch
• Abmessung: 235mm x 155mm x 18mm
• Gewicht: 600g
• ISBN-13: 9783540572398
• ISBN-10: 3540572392
• Artikelnr.: 36112080

Inhaltsangabe

Morphology.- Morphology of Dupuytren's Disease.- Interactions Between Proteoglycans and Collagen Fibrils in the Palmar Fascia in Dupuytren's Disease.- Myofibroblasts Are Not Specific to Dupuytren's Disease.- The Significance of Skin Anchoring Fibres in Palmar Fibrosis: Brief Comment.- Pathobiochemistry of Fibrillar Component.- Collagen Changes in Dupuytren's Disease.- Connective Tissue Autoantibodies in Dupuytren's Disease: Associations with HLA DR3.- Collagen Production by Cultured Dupuytren's Fibroblasts.- Proteoglycans and Glycosaminoglycans.- Proteoglycans in Biopsies of Dupuytren's Contracture.- Glycosaminoglycan Distribution Pattern in Dupuytren's Contracture Biopsies.- Biochemical Parameters for the Diagnosis of Dupuytren's Disease.- Pathobiochemistry of Cells in Dupuytren's Contracture.- Investigations of Cell Cultures Derived from Patients Suffering from Dupuytren's Contracture.- Fibroblast Gel Culture: A Model for Biochemical Investigations of Dupuytren's Contracture.- Reactivity of Cells in Nodules of Dupuytren's Contracture with Monoclonal Antibodies Recognizing Leukocyte Antigens and von Willebrand's Factor.- Demonstration of Myofibroblasts Using a Novel Murine Monoclonal Antibody, 3C2G10.7 Raised from Proliferating Cells in Dupuytren's Disease.- Reactivity of Nodular Cells in Vitro: A Guide to the Pharmacological Treatment of Dupuytren's Contracture.- Extracellular Matrix Components and Macromolecular Interactions.- Stromal-Epithelial Cell Interactions in the Mechanisms of Hepatocyte Injury, Liver Cell Regeneration and Fibrogenesis.- Proteoglycan - Collagen Fibril Interactions in Tissues.- Changes in the Biomechanical Properties of Diseased Tissue as Pathogenetic Factors in Dupuytren's Contracture.- Fibromatoses.-Localization and Morphology of Different Fibromatoses.- Thermal Stability and Fibrillogenesis of Collagen from Tissue of Patients with Dupuytren's Disease.- Macrophage Activity, Fibronectin, and SPARC Protein in Experimentally Induced Granuloma.- Modulation of Fibroblastic Cytoskeletal Features During Dupuytren's Disease.- Oxygen Free Radicals and Dupuytren's Disease.- Clinical Findings and Epidemiology of Dupuytren's Disease.- Clinical Findings in Dupuytren's Disease.- Epidemiology of Dupuytren's Disease.- Clinical Management of Dupuytren's Disease.- Limited Fasciectomy.- Fasciotomy and the Open Palm Technique.- Skin Grafting in the Management of Dupuytren's Disease.- Recurrence in Dupuytren's Disease.- Refinements of Plastic Surgery in Relapsing Dupuytren's Disease: Incisions, Flaps, Treatment of Perfusion Disorders, Physiotherapy, and Splinting.- The Complications and Unsatisfactory Results of Treatment for Dupuytren's Disease.- The Continuous Elongation Technique in Dupuytren's Disease.