Absence of durable and effective bond between the silicone soft liner and acrylic resin lead to the progressive formation of micro-gaps at the resin base-soft liner interface in silicone soft liner bonded acrylic resin prosthesis over a period of clinical use. Existence of such micro-gaps may serve as a source of micro-leakage and microbial colonization at this resin base- soft liner junction; which causes further widening of the micro-gap ultimately resulting in de-bonding of the silicone soft liner from the acrylic-resin based prosthesis.Greater the width of micro-gap formed, greater will be the potential for micro-leakage and microbial colonization, faster will be its de-bonding from the denture base and hence lower will be its durability. This book is written with an intent to rate the commonly used forms of acrylic based denture resin materials on the basis of their ability to form durable bonds with the silicone soft liner and offer suggestions to the dental clinicians regarding which acrylic based denture resin material should be preferably chosen for complete denture fabrication in cases where a silicone soft liner material is indicated.