The book reflects a conducted study aimed at investigating the effectiveness of E-learning in South African Institutions of Higher learning in compliance to the direction of lecturers' knowledge and skills of e-pedagogy, constructivism theoretical perspectives and improving quality of teaching and learning. This was an attempt to solve challenges experienced by Higher Education institutions in South African universities during the implementation of e learning programmes. In past few years, most South African institutes of higher education private and public have since adopted e learning as an approach to teaching and learning. The results indicated that E-learning in South African Institutions of Higher Education is only effective resting on improving the quality of teaching if lectures knowledge and skill in implementation of e-pedagogy, constructivism theory of learning in a blended form is high. Therefore, it is recommended, lecturers get involved in e-learning innovation programmes in terms of policy making process and implementation in order to acquire more e- pedagogical skills.