The main focus of the book was to prepare an e resource hand guide for the life science teachers practicing in secondary schools in India which will be helpful in technology integrated teaching practices or preparing instructional material. It is a problem encountered by the student -teachers or teachers that although they are well versed to teach in traditional classroom, are knowledgeable about the subject or pedagogy and also have working knowledge of Information and communication tools, they do not have enough knowledge about the pedagogical application of ICT tools in teaching and details about appropriate ICT. So to see whether availability of any such guide book is able to significantly improve the technology integrated teaching practices or able to imbibe confidence in the teachers, a handbook specifically designed for teaching Life Science was prepared.