The present study provides a detailed description of ecological features, phytochemical analysis, morpho-physiological traits, anatomical features and ultrastructure characteristics as well as biochemical aspects of yielded grains of three species of genus Echinochloa in the Nile Delta of Egypt. The sampled stands are distributed in the northern part of the Nile Delta region of Egypt which covers the north and middle limits of four Governorates namely: El-Dakahlia, Damietta, Kafr El-Sheikh and El-Behira. The results indicated that, the total number of weeds recorded in the study area is 87species belonging to 68 genera and related to 28 families. Poaceae, Asteraceae, Chenopodiaceae and Cyperaceae are the main families and representing collectively about54.11 % of the total number of recorded species in the study area. According to the life-span, the recorded weed flora can be classified into 45 perennial species (51.72%), two biennial species (2.30%) and40 annual species (45.98%).