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Till now, no study has been reported on acute toxic effects of lead exposure on Sansvieria roxburghiana. In this present investigation, we reveal lead uptake by different plant species, lead accumulation levels and antioxidative potential in plant S.roxburghiana, expression of catalase and SOD activity, lead effects on protein levels and DNA damage by RAPD analysis. Results also predicts how S.roxburghiana plant survived successfully by triggering differential pattern of antioxidative enzyme responses.