The shortage of organs for transplantation is a global problem, studies have suggested that the lack of knowledge, attitudes and other determining factors influence the decision to accept donation as a possibility for the clinical improvement of many who are waiting for a transplant. The literature review focused on the pedagogical strategies implemented in the teaching of this topic, show how the lack of knowledge influences decision-making, leading to the understanding and analysis of these results to favor the design, development and implementation of educational programs or intervention projects that increase the number of organ donations and minimize the barriers that exist. This review reveals that the understanding of the processes and the knowledge acquired, independent of their conviction, will lead to the modification of behaviors in donation and transplantation.