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Fasting is the biological condition when animals are unable to eat due to an extrinsic limitation on their food supply, however fasting means that animals cannot eat due to intrinsic factors, while food is available. Starvation or fasting refers to a complete exclusion of all food except water. In this study, it was noticed that, acute fasting causes an oblivious reduction in the body and organ weight as well as it leads to histological and chemical alteration i.e. shrinkage of columnar cells, dilation of mucus secreting cells and reduction in neutral mucusubstances respectively. In conclusion, starvation induced structural changes in intestine which were directly proportional to fasting period.