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Objective: To identify effect of ethyl alcohol extract of three plants, Cimetidine and Albendazole drugs in Hydatid Cysts disease in vitro and in vivo. Result: The median lethal dose (LD50) for (Peganum harmala seeds,Zizyphus spina-christi and Olea europaea leaves) was estimated (487.5,4000,3500) mg/kg receptively. In vivo, the effect of ethyl alcohol extracts of Peganum harmala seeds in different doses(30,60) mg/kg and Cimetidine (3,6) mg/kg was studied on secondary hydatidosis in laboratory