Effect of Carbofuran on the histology of liver of rabbits - Iqbal, Nida;Nazir, Sumra
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The modern man is constantly exposed to a variety of toxic chemicals primarily due to changes in life style. Among all classes of pesticides, carbamates are most commonly used compounds because OPs and OCls are extremely toxic and possess delayed neurotoxic effects. Toxicological characteristics of the N-methyl carbamates involve maximal cholinesterase enzyme inhibition followed by a rapid recovery, typically from minutes to hours. Among other pesticides, carbamates have been included in the list of known endocrine disruptor compounds.The accumulation of carbofuran in animals and humans may…mehr

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Produktbeschreibung
The modern man is constantly exposed to a variety of toxic chemicals primarily due to changes in life style. Among all classes of pesticides, carbamates are most commonly used compounds because OPs and OCls are extremely toxic and possess delayed neurotoxic effects. Toxicological characteristics of the N-methyl carbamates involve maximal cholinesterase enzyme inhibition followed by a rapid recovery, typically from minutes to hours. Among other pesticides, carbamates have been included in the list of known endocrine disruptor compounds.The accumulation of carbofuran in animals and humans may take place via ingestion of pesticide-contaminated food and water as well as accidental or occupational poisoning.The liver is the primary organ involved in xenobiotic metabolism and is a major target organ of chemicals and drugs. Hepatotoxicity is therefore an important end point in the evaluation of the effect of a particular xenobiotic. Clinical chemistry and histopathological evaluations are commonly used methods for detecting organ specific effects related to chemical exposure. Liver showed hypertrophy of hepatocytes within 8 hours after the injection of the pesticide.
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Autorenporträt
Dr. Nida Iqbal is a Senior Lecturer at Faculty of Biosciences and Medical Engineering (FBME) in University Technology Malaysia (UTM), Malaysia. She has obtained her Ph.D in Biomedical Engineering from UTM, Malaysia and MS/BS in Chemistry from Punjab University Lahore, Pakistan. She has over 7 years of experience in teaching and Biomedical research.