Cypermethrin and carbendazim are synthetic pesticides that have been in use for more than a decade. Low-dose and time dependent effect of these pesticides in male albino rat serum will highlight early hematological changes. Cypermethrin and carbendazim were administered in individual and combined form at 5, 10, 25 and 50mM for durations of 12 and 24 h in the different group of rats. The results of the study displayed the hematological changes in rat blood. Hematological markers such as Hemoglobin, Red Blood Cells, White Blood Cells, Neutrophils, Eosinophil, Lymphocytes and Platelet were significantly changed in male albino rat following the administration of these pesticides at different concentration. Observation of changes in these hematological markers confirmed an inference. The overall experimental results suggest that even low dose of these pesticides has a significant negative effect on animal cell function.