pain management during endodontic procedures and after postoperative stage is one of the most important goals of dentists. Injury to the periapical tissues around the root of the tooth undergoing root canal treatment is the most common cause of postendodontic pain. cryotherapy is a long standing technique that has been frequently applied in sports injuries and surgical procedures for pain management and postoperative care. In the field of endodontics, cryotherapy has been frequently used following periapical surgical procedures and during root canal treatment to reduce postoperative pain. The objective of this systematic review and meta-analysis is to evaluate the effect of intracanal cryotherapy on postendodontic pain after root canal therapy.