Soluble fertilizer dissolve easily in water and are immediately available to the crops. Split application of soluble fertilizer ensures required nutrients in right quantity for getting higher yield with minimum loss of nutrients.With this view field experiment was conducted during kharif season of 2013-2014 at Research farm, Department of Soil Science and Agricultural chemistry, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani. The experiment was carried out in randomized block design with four replication and five treatments comprised of 100 per cent, 80 per cent and 60 per cent. RDF through water soluble fertilizers through drip, 100 per cent RDF of conventional fertilizers through drip (urea, phosphoric acid and sulphate of potash) and 100 per cent RDF of conventional fertilizers through soil application. The recommended NPK dose through soluble fertilizers in splits improves growth, yield and quality parameters of Bt Cotton.