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Nursing students experience a considerable amount of stress to meet their professional demands both academic and clinical requirements. However, yoga is an effective practice to reduce stress and improve psychological and physical well-being.AIM To evaluate the effectiveness of an 8-week yoga intervention on psycho-physical functioning of nursing students. MATERIALS AND METHODS This was a randomized wait-list control trial. We recruited 100 students from Kempegowda Institute of Nursing, Bangalore, and randomized them into two groups (yoga=50 and wait-list control=50 students). The following instruments were used to collect the data, Freiburg Mindfulness Inventory (FMI), Self-Compassion Scale- short form (SCS-SF), Connor- Davidson Resilience Scale (CD-RISC), Satisfaction with Life Scale (SWLS), Jefferson Scale of Empathy HPS-Version (JSE-HPS), Perceived Stress Scale (PSS), Sit and Reach Test, Peak Flow Meter, Handgrip Dynamometer, Pinch Gauge, and Purdue Pegboard. Data was analyzed using Repeated Measures Analysis of Variance (RM-ANOVA) followed by post-hoc Bonferroni correction for all the variables. CONCLUSION Overall, the present study has demonstrated mixed results. Though we could not elucidate significant improvements in all the variables, an increase in mindfulness, self-compassion, low back, and hamstring flexibility, and pinch strength is worth noting. This improvement in psycho-physical functioning aid nursing students to meet the demands of the profession. Hence, yoga intervention can be recommended in nursing education.