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Depression and anxiety are common in patients with type 2 diabetes, adversely affecting quality of life, diabetes outcomes, and mortality. Depression, anxiety and uncontrolled blood glucose are disorder symptoms can be effectively treated with psycho-educational therapy based on cognitive behavior therapy (CBT), body, mind and spirit therapy. This book explaine the effectiveness of psycho-educational intervention program on anxiety, depression and blood glucose level of patients with type II Diabetes Mellitus in Gaza Strip.