Effects of Cartilage Impact on Chondrocyte Viability and TLR-Ligands - Stolberg-Stolberg, Josef
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The development of post-traumatic arthritis involves chondrocyte death and inflammation of cartilage and surrounding tissues. Two invitro loading apparatus were designed to investigate the effect of trauma mechanism on chondrocyte viability and the release of Toll-like receptor (TLR) activating ligands. This study shows that low strain blunt impact 70% strain causes mainly apoptotic chondrocyte death whereas high strain blunt impact 80% strain and cartilage fracture lead to necrosis. Cartilage debris released from injured osteochondral cores is able to induce inflammation via TLR activation.

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Produktbeschreibung
The development of post-traumatic arthritis involves chondrocyte death and inflammation of cartilage and surrounding tissues. Two invitro loading apparatus were designed to investigate the effect of trauma mechanism on chondrocyte viability and the release of Toll-like receptor (TLR) activating ligands. This study shows that low strain blunt impact 70% strain causes mainly apoptotic chondrocyte death whereas high strain blunt impact 80% strain and cartilage fracture lead to necrosis. Cartilage debris released from injured osteochondral cores is able to induce inflammation via TLR activation.
Autorenporträt
Dr. med. Josef Stolberg-Stolberg studied medicine at the Technische Universität München and Tecnológico de Monterrey, Mexico. His doctoral thesis was conducted at the Duke University in Durham, NC. He is now employed at the Department for Trauma-, Hand- and Reconstructive Surgery of the Wilhelms-University of Münster, Germany.